Integrated metabolomic, lipidomic and proteomic analysis define the metabolic changes occurring in curled areas in leaves with leaf peach curl disease

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dc.citation.titlePlant, Cell & Environment
dc.citation.volume48
dc.contributor.orcidhttps://orcid.org/0000-0003-4914-0242
dc.creatorNovello, María Angelina
dc.creatorBustamante, Claudia Anabel
dc.creatorSvetaz, Laura Andrea
dc.creatorGoldy, Camila
dc.creatorValentini, Gabriel Hugo
dc.creatorDrincovich, María Fabiana
dc.creatorBrotman, Yariv
dc.creatorFernie, Alisdair R.
dc.creatorLara, María Valeria
dc.date.accessioned2025-02-26T13:36:10Z
dc.date.available2025-02-26T13:36:10Z
dc.date.issued2025-06-02
dc.description.abstractPeach Leaf Curl Disease, caused by Taphrina deformans, is characterized by reddish hypertrophic and hyperplasic leaf areas. To comprehend the biochemical imbalances caused by the fungus, dissected symptomatic (C) and asymptomatic areas (N) from leaves with increasing disease extension were analyzed by an integrated approach including metabolomics, lipidomics, proteomics, and complementary biochemical techniques. Drastic metabolic differences were identified in C areas with respect to either N areas or healthy leaves, including altered chloroplastic functioning and composition, which differs from the typical senescence process. In C areas, alteration in redox-homoeostasis proteins and in triacylglycerols content, peroxidation and double bond index were observed. Proteomic data revealed induction of host enzymes involved in auxin and jasmonate biosynthesis and an upregulation of phenylpropanoid and mevalonate pathways and downregulation of the plastidic methylerythritol phosphate route. Amino acid pools were affected, with upregulation of proteins involved in asparagine synthesis. Curled areas exhibited a metabolic shift towards functioning as a sink tissue importing sugars, probably from N areas, and producing energy through fermentation and respiration and reductive power via the pentose phosphate route. Identifying the metabolic disturbances leading to disease symptoms is a key step in designing strategies to prevent or delay the progression of the disease.
dc.description.filFil: Novello, María Angelina. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Centro de Estudios Fotosintéticos y Bioquímicos (CEFOBI); Argentina.
dc.description.filFil: Bustamante, Claudia Anabel. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Centro de Estudios Fotosintéticos y Bioquímicos (CEFOBI); Argentina.
dc.description.filFil: Svetaz, Laura Andrea. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Centro de Estudios Fotosintéticos y Bioquímicos (CEFOBI); Argentina.
dc.description.filFil: Goldy, Camila. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Centro de Estudios Fotosintéticos y Bioquímicos (CEFOBI); Argentina.
dc.description.filFil: Valentini, Gabriel Hugo. Instituto Nacional de Tecnología Agropecuaria. Estación Experimental Agropecuaria San Pedro; Argentina.
dc.description.filFil: Drincovich, María Fabiana. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Centro de Estudios Fotosintéticos y Bioquímicos (CEFOBI); Argentina.
dc.description.filFil: Brotman, Yariv. Tel Aviv Universit. The George S. Wise Faculty of Life Sciences. School of Plant Sciences and Food Security; Israel.
dc.description.filFil: Fernie, Alisdair R. Max-Planck-Institut für Molekulare Pflanzenphysiologie; Germany.
dc.description.filFil: Lara, María Valeria. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Centro de Estudios Fotosintéticos y Bioquímicos (CEFOBI); Argentina.
dc.description.sponsorshipAgencia Nacional de Promoción de la Investigación, el Desarrollo Tecnológico y la Innovación (Agencia I+D+i): PICT 2016-0819
dc.description.versionpeerreviewed
dc.format.extent1-22
dc.identifier.citationNovello, M. A., Bustamante, C. A., Svetaz, L. A., Goldy, C., Valentini, G. H., Drincovich, M. F., Brotman, Y., Fernie, A. R. and Lara, M. V. (2025). Integrated metabolomic, lipidomic and proteomic analysis define the metabolic changes occurring in curled areas in leaves with leaf peach curl disease. Plant, Cell & Environment, 48(2), 1179-1200. https://doi.org/10.1111/pce.15210
dc.identifier.e-issn1365-3040
dc.identifier.issn0140-7791
dc.identifier.urihttps://hdl.handle.net/2133/28951
dc.language.isoen
dc.publisherWiley
dc.relation.publisherversionhttps://doi.org/10.1111/pce.15210
dc.relation.publisherversionhttps://onlinelibrary.wiley.com/doi/10.1111/pce.15210
dc.rightsopenAccess
dc.rights.holderNovello, María Angelina
dc.rights.holderBustamante, Claudia Anabel
dc.rights.holderSvetaz, Laura Andrea
dc.rights.holderGoldy, Camila
dc.rights.holderValentini, Gabriel Hugo
dc.rights.holderDrincovich, María Fabiana
dc.rights.holderBrotman, Yariv
dc.rights.holderFernie, Alisdair R.
dc.rights.holderLara, María Valeria
dc.rights.holderUniversidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas
dc.rights.textAttribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectDefence
dc.subjectPhytohormones
dc.subjectPrunus persica
dc.subjectTaphrina deformans
dc.subjectPeach tree
dc.titleIntegrated metabolomic, lipidomic and proteomic analysis define the metabolic changes occurring in curled areas in leaves with leaf peach curl disease
dc.typearticulo
dc.type.collectionarticulo
dc.type.versionpublishedVersion

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