Identification of novel chemical scaffolds Inhibiting trypanothione synthetase from pathogenic trypanosomatids

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dc.citation.titlePLOS Neglected Tropical Diseaseses
dc.citation.volume10(4)es
dc.creatorBenítez, Diego
dc.creatorMedeiros, Andrea
dc.creatorFiestas, Lucía
dc.creatorPanozzo Zénere, Esteban Andrés
dc.creatorMaiwald, Franziska
dc.creatorProusis, Kyriakos C.
dc.creatorRoussaki, Marina
dc.creatorCalogeropoulou, Theodora
dc.creatorDetsi, Anastasia
dc.creatorJaeger, Timo
dc.creatorŠarlauskas, Jonas
dc.creatorPeterlin Mašič, Lucíja
dc.creatorKunick, Conrad
dc.creatorLabadie, Guillermo Roberto
dc.creatorFlohé, Leopold
dc.creatorComini, Marcelo A.
dc.date.accessioned2020-12-22T17:52:45Z
dc.date.available2020-12-22T17:52:45Z
dc.date.issued2016-04-12
dc.descriptionThe search for novel chemical entities targeting essential and parasite-specific pathways is considered a priority for neglected diseases such as trypanosomiasis and leishmaniasis. The thiol-dependent redox metabolism of trypanosomatids relies on bis-glutathionylspermidine [trypanothione, T(SH)2], a low molecular mass cosubstrate absent in the host. In pathogenic trypanosomatids, a single enzyme, trypanothione synthetase (TryS), catalyzes trypanothione biosynthesis, which is indispensable for parasite survival. Thus, TryS qualifies as an attractive drug target candidate.es
dc.descriptionPara citar este articulo: Benítez D, Medeiros A, Fiestas L, PanozzoZenere EA, Maiwald F, Prousis KC, et al. (2016) Identification of Novel Chemical Scaffolds Inhibiting Trypanothione Synthetase from Pathogenic Trypanosomatids. PLoS Negl Trop Dis 10(4): e0004617. doi:10.1371/journal.pntd.0004617
dc.description.filFil: Benítez, Diego. Institut Pasteur de Montevideo. Laboratorio de Biologia Redox de Tripanosomátidos; Uruguay.es
dc.description.filFil: Medeiros, Andrea. Institut Pasteur de Montevideo. Laboratorio de Biología Redox de Tripanosomátidos; Uruguay.es
dc.description.filFil: Medeiros, Andrea. Universidad de la República. Departamento de Bioquímica; Uruguay.es
dc.description.filFil: Fiestas, Lucía. Institut Pasteur de Montevideo. Laboratorio de Biologia Redox de Tripanosomátidos; Uruguay.es
dc.description.filFil: Panozzo Zénere, Esteban Andrés. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Química Rosario (IQUIR-CONICET); Argentinaes
dc.description.filFil: Maiwald, Franziska. Technische Universität Braunschweig. Institut für Medizinische und Pharmazeutische Chemie; Deutschland.es
dc.description.filFil: Prousis, Kyriakos C. National Hellenic Research Foundation. Institute of Biology, Medicinal Chemistry and Biotechnology; Greece.es
dc.description.filFil: Roussaki, Marina. National Technical University of Athens. School of Chemical Engineering. Laboratory of Organic Chemistry; Greece.es
dc.description.filFil: Calogeropoulou, Theodora. National Hellenic Research Foundation. Institute of Biology, Medicinal Chemistry and Biotechnology; Greece.es
dc.description.filFil: Detsi, Anastasia. National Technical University of Athens. School of Chemical Engineering. Laboratory of Organic Chemistry; Greece.es
dc.description.filFil: Jaeger, Timo. German Centre for Infection Research, Braunschweig; Germany.es
dc.description.filFil: Šarlauskas, Jonas. Vilnius University. Department of the Biochemistry of Xenobiotics Institute of Biochemistry; Lithuania.es
dc.description.filFil: Peterlin Mašič, Lucíja. University of Ljubljana. Faculty of Pharmacy. Department for Medicinal Chemistry; Slovenia.es
dc.description.filFil: Kunick, Conrad. Technische Universität Braunschweig. Institut für Medizinische und Pharmazeutische Chemie; Deutschland.es
dc.description.filFil: Labadie, Guillermo Roberto. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Química Rosario (IQUIR -CONICET); Argentina.es
dc.description.filFil: Flohé, Leopold. Universidad de la República. Departamento de Bioquímica; Uruguay.es
dc.description.filFil: Flohé, Leopold. Università degli Studi di Padova. Department of Molecular Medicine; Italy.es
dc.description.filFil: Comini, Marcelo A. Institut Pasteur de Montevideo. Laboratorio de Biologia Redox de Tripanosomátidos; Uruguay.es
dc.description.sponsorshipAgencia Nacional de Investigación e Innovación (ANII): POS_NAC_2013_1_114477, POS_NAC_2011_1_3284 y project DCI-ALA/2007/19.040es
dc.description.sponsorshipFondo para la Convergencia Estructural del MERCOSUR (FOCEM)es
dc.description.sponsorshipActions Concertees Internationales Pasteuriennes (ACIP): call 2015, project ACIP 17-2015es
dc.description.sponsorshipComisión Sectorial de Investigación Científicaes
dc.description.sponsorshipUniversidad de la Republica: project nr. 3404es
dc.description.sponsorshipEuropean Cooperation in Science and Technology (COST): Action CM0801es
dc.description.sponsorshipGerman Bundesministerium für Bildung und Forschung: KMU innovativ 5, Förderkennzeichen 0315814es
dc.formatapplication/pdf
dc.format.extent1-25es
dc.identifier.issn1935-2735es
dc.identifier.urihttp://hdl.handle.net/2133/19536
dc.language.isoenges
dc.publisherPublic Library of Science (PLOS)es
dc.relation.publisherversionhttps://doi.org/10.1371/journal.pntd.0004617es
dc.relation.publisherversionhttps://journals.plos.org/plosntds/article?id=10.1371/journal.pntd.0004617es
dc.rightsopenAccesses
dc.rights.holderUniversidad Nacional de Rosarioes
dc.rights.holderBenítez, Diegoes
dc.rights.holderMedeiros, Andreaes
dc.rights.holderFiestas, Lucíaes
dc.rights.holderPanozzo Zénere, Esteban Andréses
dc.rights.holderMaiwald, Franziskaes
dc.rights.holderProusis, Kyriakos C.es
dc.rights.holderRoussaki, Marinaes
dc.rights.holderCalogeropoulou, Theodoraes
dc.rights.holderDetsi, Anastasiaes
dc.rights.holderJaeger, Timoes
dc.rights.holderŠarlauskas, Jonases
dc.rights.holderPeterlin Mašič, Lucíjaes
dc.rights.holderKunick, Conrades
dc.rights.holderLabadie, Guillermo Robertoes
dc.rights.holderFlohé, Leopoldes
dc.rights.holderComini, Marcelo A.es
dc.rights.textAttribution 4.0 International (CC BY 4.0)es
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/*
dc.subjectNeglected Diseaseses
dc.subjectTrypanothione Synthetase Inhibitorses
dc.subjectPathogenic Trypanosomatidses
dc.subjectLeishmaniaes
dc.subjectTrypanosomaes
dc.titleIdentification of novel chemical scaffolds Inhibiting trypanothione synthetase from pathogenic trypanosomatidses
dc.typearticle
dc.typeartículo
dc.typepublishedVersion
dc.type.collectionarticulo
dc.type.versionpublishedVersiones

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