Identification of novel chemical scaffolds Inhibiting trypanothione synthetase from pathogenic trypanosomatids

Resumen
The search for novel chemical entities targeting essential and parasite-specific pathways is considered a priority for neglected diseases such as trypanosomiasis and leishmaniasis. The thiol-dependent redox metabolism of trypanosomatids relies on bis-glutathionylspermidine [trypanothione, T(SH)2], a low molecular mass cosubstrate absent in the host. In pathogenic trypanosomatids, a single enzyme, trypanothione synthetase (TryS), catalyzes trypanothione biosynthesis, which is indispensable for parasite survival. Thus, TryS qualifies as an attractive drug target candidate.

Palabras clave

Neglected Diseases, Trypanothione Synthetase Inhibitors, Pathogenic Trypanosomatids, Leishmania, Trypanosoma

Citación