Identification of novel chemical scaffolds Inhibiting trypanothione synthetase from pathogenic trypanosomatids
Cargando...
Archivos
Fecha
Título de la revista
ISSN de la revista
Título del volumen
Editor
Public Library of Science (PLOS)
Resumen
Descripción
The search for novel chemical entities targeting essential and parasite-specific pathways is
considered a priority for neglected diseases such as trypanosomiasis and leishmaniasis.
The thiol-dependent redox metabolism of trypanosomatids relies on bis-glutathionylspermidine [trypanothione, T(SH)2], a low molecular mass cosubstrate absent in the host. In pathogenic trypanosomatids, a single enzyme, trypanothione synthetase (TryS), catalyzes
trypanothione biosynthesis, which is indispensable for parasite survival. Thus, TryS qualifies as an attractive drug target candidate.
Para citar este articulo: Benítez D, Medeiros A, Fiestas L, PanozzoZenere EA, Maiwald F, Prousis KC, et al. (2016) Identification of Novel Chemical Scaffolds Inhibiting Trypanothione Synthetase from Pathogenic Trypanosomatids. PLoS Negl Trop Dis 10(4): e0004617. doi:10.1371/journal.pntd.0004617
Para citar este articulo: Benítez D, Medeiros A, Fiestas L, PanozzoZenere EA, Maiwald F, Prousis KC, et al. (2016) Identification of Novel Chemical Scaffolds Inhibiting Trypanothione Synthetase from Pathogenic Trypanosomatids. PLoS Negl Trop Dis 10(4): e0004617. doi:10.1371/journal.pntd.0004617
Citación
Aprobación
Revisión
Complementado por
Referenciado por
Licencia Creative Commons
Excepto donde se indique lo contrario, la licencia de este ítem se describe como Attribution 4.0 International (CC BY 4.0)