Tuberculosis, the Disrupted Immune-Endocrine Response and the Potential Thymic Repercussion As a Contributing Factor to Disease Physiopathology

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dc.citation.titleFrontiers in endocrinologyes
dc.citation.volume9:214es
dc.creatorD'Attilio, Luciano
dc.creatorSantucci, Natalia
dc.creatorBongiovanni, Bettina
dc.creatorBay, María Luisa
dc.creatorBottasso, Oscar
dc.date.accessioned2019-04-15T13:57:19Z
dc.date.available2019-04-15T13:57:19Z
dc.date.issued2018-05-01
dc.descriptionUpon the pathogen encounter, the host seeks to ensure an adequate inflammatory reaction to combat infection but at the same time tries to prevent collateral damage, through several regulatory mechanisms, like an endocrine response involving the production of adrenal steroid hormones. Our studies show that active tuberculosis (TB) patients present an immune-endocrine imbalance characterized by an impaired cellular immunity together with increased plasma levels of cortisol, pro-inflammatory cytokines, and decreased amounts of dehydroepiandrosterone. Studies in patients undergoing specific treatment revealed that cortisol levels remained increased even after several months of initiating therapy. In addition to the well-known metabolic and immunological effects, glucocorticoids are involved in thymic cortical depletion with immature thymocytes being quite sensitive to such an effect. The thymus is a central lymphoid organ supporting thymocyte T-cell development, i.e., lineage commitment, selection events and thymic emigration. While thymic TB is an infrequent manifestation of the disease, several pieces of experimental and clinical evidence point out that the thymus can be infected by mycobacteria. Beyond this, the thymic microenvironment during TB may be also altered because of the immune-hormonal alterations. The thymus may be then an additional target of organ involvement further contributing to a deficient control of infection and disease immunopathology.es
dc.description.filFil: D'Attilio, Luciano. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Instituto de Inmunología Clínica y Experimental de Rosario, CONICET-UNR; Argentinaes
dc.description.filFil: Bottasso, Oscar. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Instituto de Inmunología Clínica y Experimental de Rosario, CONICET-UNR; Argentinaes
dc.formatapplication/pdf
dc.format.extent1-9es
dc.identifier.issn1664-2392es
dc.identifier.urihttp://hdl.handle.net/2133/14382
dc.language.isoenges
dc.publisherFrontiers Research Foundationes
dc.relation.publisherversionhttps://dx.doi.org/10.3389%2Ffendo.2018.00214es
dc.rightsopenAccesses
dc.rights.holder© 2018 D’Attilio, Santucci, Bongiovanni, Bay and Bottassoes
dc.rights.texthttps://creativecommons.org/licenses/by/4.0/es
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/*
dc.subjectTuberculosises
dc.subjectImmune-endocrine communicationes
dc.subjectInflammationes
dc.subjectThymic involutiones
dc.subjectPathophysiologyes
dc.subjectHormoneses
dc.titleTuberculosis, the Disrupted Immune-Endocrine Response and the Potential Thymic Repercussion As a Contributing Factor to Disease Physiopathologyes
dc.typearticle
dc.typeartículo
dc.typepublishedVersion
dc.type.collectionarticulo
dc.type.versionpublishedVersiones

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FCM - Instituto de Inmunología - Artículos de Investigación
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