Trypanosoma cruzi High Mobility Group B (TcHMGB) can act as an inflammatory mediator on mammalian cells

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dc.citation.titlePLoS Neglected Tropical Diseases (PLoS NTDs)
dc.citation.volume11(2)
dc.creatorCribb, Pamela
dc.creatorPerdomo, Virginia Gabriela
dc.creatorAlonso, Victoria Lucía
dc.creatorManarin, Romina
dc.creatorBarrios-Payán, Jorge
dc.creatorMarquina-Castillo, Brenda
dc.creatorTavernelli, Luis
dc.creatorHernández-Pando, Rogelio
dc.date.accessioned2021-03-16T18:27:14Z
dc.date.available2021-03-16T18:27:14Z
dc.date.issued2017-02-08
dc.descriptionWhen an infection occurs, the innate immune cells recognize Pathogen Associated Molec ular Patterns (PAMPs) through their Pattern Recognition Receptors. This triggers an inflammatory response intended to kill the foreign microbe. But inflammation can also be triggered by the recognition of endogenous molecules called “Danger (or Damage) Asso ciated Molecular Patterns” (DAMPs) that are released by damaged or necrotic cells to “ring the alarm” of the immune system that repair is needed, so some of them are also known as “alarmins”. High Mobility group box 1 protein (HMGB1) is a prototypical alar min molecule released by injured cells and it is also actively secreted by cells of the innate immune system in response to invasion as well as to sterile damage. Trypanosoma cruzi, the causal agent of Chagas Disease, has its own HMGB protein that we called TcHMGB. Using in vitro and in vivo experimental systems, we demonstrated for the first time that TcHMGB is able to mediate inflammation on mammalian cells, inducing the expression of both pro-inflammatory and anti-inflammatory cytokines. Our results suggest that the parasite´s protein could have a role in the immune response and the pathogenesis of Cha gas disease, probably overlapping to some extent with the host cell DAMP molecules´ functions.es
dc.descriptionPara citar este articulo: Cribb P, Perdomo V, Alonso VL, Manarin R, Barrios-Paya´n J, Marquina-Castillo B, et al. (2017) Trypanosoma cruzi High Mobility Group B (TcHMGB) can act as an inflammatory mediator on mammalian cells. PLoS Negl Trop Dis 11(2): e0005350. doi:10.1371/journal.pntd.0005350
dc.description.filFil: Cribb, Pamela. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Biología Molecular y Celular de Rosario (IBR -CONICET); Argentina.
dc.description.filFil: Cribb, Pamela. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas; Argentina.
dc.description.filFil: Perdomo, Virginia Gabriela. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Biología Molecular y Celular de Rosario (IBR -CONICET); Argentina.
dc.description.filFil: Perdomo, Virginia Gabriela. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas; Argentina.
dc.description.filFil: Alonso, Victoria Lucía. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas; Argentina.
dc.description.filFil: Manarin, Romina. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas; Argentina.
dc.description.filFil: Barrios-Payán, Jorge. Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán. Sección de Patología Experimental; México.
dc.description.filFil: Marquina-Castillo, Brenda. Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán. Sección de Patología Experimental; México.
dc.description.filFil: Tavernelli, Luis. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Biología Molecular y Celular de Rosario (IBR -CONICET); Argentina.
dc.description.filFil: Hernández-Pando, Rogelio. Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán. Sección de Patología Experimental; México.
dc.description.sponsorshipConsejo Nacional de Investigaciones Científicas y Técnicas Argentina-Consejo Nacional de Ciencia y Tecnología México: Bilateral International Project Argentina-Mexico number 190527es
dc.description.sponsorshipFundación Bunge y Born: Subsidios para Investigación de la Enfermedad de Chagas 2012es
dc.description.sponsorshipConsejo Nacional de Investigaciones Científicas y Técnicas (CONICET): PIP 2011-01-00372es
dc.formatapplication/pdf
dc.format.extent1-22
dc.identifier.issn1935-2735
dc.identifier.urihttp://hdl.handle.net/2133/20196
dc.language.isoenges
dc.publisherPublic Library of Science (PLOS)es
dc.relation.publisherversionhttps://doi.org/10.1371/journal.pntd.0005350es
dc.relation.publisherversionhttps://journals.plos.org/plosntds/article?id=10.1371/journal.pntd.0005350es
dc.rightsopenAccesses
dc.rights.holderUniversidad Nacional de Rosarioes
dc.rights.holderCribb, Pamelaes
dc.rights.holderPerdomo, Virginia Gabrielaes
dc.rights.holderAlonso, Victoria Lucíaes
dc.rights.holderManarin, Rominaes
dc.rights.holderBarrios-Payán, Jorgees
dc.rights.holderMarquina-Castillo, Brendaes
dc.rights.holderTavernelli, Luises
dc.rights.holderHernández-Pando, Rogelioes
dc.rights.textAttribution 4.0 International (CC BY 4.0)es
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/*
dc.subjectHigh Mobility Group B Proteinses
dc.subjectTrypanosoma cruzies
dc.subjectDamage-associated Molecular Patternses
dc.subjectInflammationes
dc.titleTrypanosoma cruzi High Mobility Group B (TcHMGB) can act as an inflammatory mediator on mammalian cellses
dc.typepublishedVersion

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