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Virulence role of the outer membrane protein CarO in carbapenem-resistant Acinetobacter baumannii

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7.pdf (3,77 MB)

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2020-12-10

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Taylor & Francis

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Novel approaches to treat carbapenem-resistant Acinetobacter baumannii (CRAB) infections are urgently needed and anti-virulence drugs represent promising alternatives, but our knowledge on potential targets is scarce. We searched for potential A. baumannii virulence factors by whole-genome sequencing-based comparisons of CRAB clinical isolates causing bloodstream infections secondary to ventilator-associated pneumonia from demographics and clinically homogeneous patients, who received optimal treatment but with different clinical outcomes. Thus, the carO gene was interrupted in CRAB isolates from surviving patients, while it was intact in isolates from non-surviving patients, and proteomic/immunoblot techniques corroborated it. When the viru lence role of A. baumannii CarO was analyzed in model systems, isogenic ΔcarO mutants and a CRAB clinical isolate with truncated CarO, showed lower ability to adhere and invade A549 cells and in vivo virulence. This unnoticed virulence role for CarO postulate this A. baumannii outer membrane protein as a potential target for new therapies against CRAB infections.
Para citar este articulo: Gema Labrador-Herrera, Antonio J. Pérez-Pulido, Rocío Álvarez-Marín, Carlos S. Casimiro-Soriguer, Tania Cebrero-Cangueiro, Jorgelina Morán-Barrio, Jerónimo Pachón, Alejandro M. Viale & María Eugenia Pachón-Ibáñez (2020) Virulence role of the outer membrane protein CarO in carbapenem-resistant Acinetobacter baumannii, Virulence, 11:1, 1727-1737, DOI: 10.1080/21505594.2020.1855912

Palabras clave

Acinetobacter baumannii, Bloodstream Infections, Carbapenems Resistance, Whole-genome Sequencing, Virulence Factors, CarO

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http://hdl.handle.net/2133/20527

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(FBIOyF) Departamento de Microbiología - Artículos

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Attribution 4.0 International (CC BY 4.0)
Excepto donde se indique lo contrario, la licencia de este ítem se describe como Attribution 4.0 International (CC BY 4.0)