Quorum and light signals modulate acetoin/butanediol catabolism in Acinetobacter spp

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dc.citation.titleFrontiers in Microbiology
dc.citation.volume10
dc.creatorTuttobene, Marisel Romina
dc.creatorFernández-García, Laura
dc.creatorBlasco, Lucía
dc.creatorCribb, Pamela
dc.creatorAmbroa, Anton
dc.creatorMüller, Gabriela Leticia
dc.creatorFernández-Cuenca, Felipe
dc.creatorBleriot, Inés
dc.creatorRodríguez, Ramiro Esteban
dc.creatorBarbosa, Beatriz G. V.
dc.creatorLopez-Rojas, Rafael
dc.creatorTrastoy, Rocío
dc.creatorLópez, María
dc.creatorBou, Germán
dc.creatorTomás, María
dc.creatorMussi, María Alejandra
dc.date.accessioned2021-03-09T19:02:23Z
dc.date.available2021-03-09T19:02:23Z
dc.date.issued2019-06-20
dc.descriptionAcinetobacter spp. are found in all environments on Earth due to their extraordinary capacity to survive in the presence of physical and chemical stressors. In this study, we analyzed global gene expression in airborne Acinetobacter sp. strain 5-2Ac02 isolated from hospital environment in response to quorum network modulators and found that they induced the expression of genes of the acetoin/butanediol catabolism, volatile compounds shown to mediate interkingdom interactions. Interestingly, the acoN gene, annotated as a putative transcriptional regulator, was truncated in the downstream regulatory region of the induced acetoin/butanediol cluster in Acinetobacter sp. strain 5-2Ac02, and its functioning as a negative regulator of this cluster integrating quorum signals was confirmed in Acinetobacter baumannii ATCC 17978. Moreover, we show that the acetoin catabolism is also induced by light and provide insights into the light transduction mechanism by showing that the photoreceptor BlsA interacts with and antagonizes the functioning of AcoN in A. baumannii, integrating also a temperature signal. The data support a model in which BlsA interacts with and likely sequesters AcoN at this condition, relieving acetoin catabolic genes from repression, and leading to better growth under blue light. This photoregulation depends on temperature, occurring at 23◦C but not at 30◦C. BlsA is thus a dual regulator, modulating different transcriptional regulators in the dark but also under blue light, representing thus a novel concept. The overall data show that quorum modulators as well as light regulate the acetoin catabolic cluster, providing a better understanding of environmental as well as clinical bacteria.es
dc.descriptionPara citar este articulo: Tuttobene MR, Fernández-García L, Blasco L, Cribb P, Ambroa A, Müller GL, Fernández-Cuenca F, Bleriot I, Rodríguez RE, Barbosa BGV, Lopez-Rojas R, Trastoy R, López M, Bou G, Tomás M and Mussi MA (2019) Quorum and Light Signals Modulate Acetoin/Butanediol Catabolism in Acinetobacter spp. Front. Microbiol. 10:1376. doi: 10.3389/fmicb.2019.01376
dc.description.filFil: Tuttobene, Marisel Romina. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Centro de Estudios Fotosintéticos y Bioquímicos (CEFOBI -CONICET); Argentina.
dc.description.filFil: Fernández-García, Laura. University of A Coruña (UDC). Hospital A Coruña (CHUAC). Microbiology Department-Biomedical Research Institute A Coruña (INIBIC); Spain.
dc.description.filFil: Blasco, Lucía. University of A Coruña (UDC). Hospital A Coruña (CHUAC). Microbiology Department-Biomedical Research Institute A Coruña (INIBIC); Spain.
dc.description.filFil: Cribb, Pamela. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Biología Molecular y Celular de Rosario (IBR -CONICET); Argentina.
dc.description.filFil: Ambroa, Anton. University of A Coruña (UDC). Hospital A Coruña (CHUAC). Microbiology Department-Biomedical Research Institute A Coruña (INIBIC); Spain.
dc.description.filFil: Müller, Gabriela Leticia. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Centro de Estudios Fotosintéticos y Bioquímicos (CEFOBI -CONICET); Argentina.
dc.description.filFil: Fernández-Cuenca, Felipe. Hospital Universitario Virgen Macarena. Clinical Unit for Infectious Diseases, Microbiology and Preventive Medicine; Spain.
dc.description.filFil: Fernández-Cuenca, Felipe. University of Seville. Department of Microbiology and Medicine; Spain.
dc.description.filFil: Fernández-Cuenca, Felipe. Instituto de Biomedicina de Sevilla (IBIS); España.
dc.description.filFil: Bleriot, Inés. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Centro de Estudios Fotosintéticos y Bioquímicos (CEFOBI -CONICET); Argentina.
dc.description.filFil: Rodríguez, Ramiro Esteban. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Biología Molecular y Celular de Rosario (IBR -CONICET); Argentina.
dc.description.filFil: Barbosa, Beatriz G. V. University of Pernambuco. Biological Sciences Institute. Microbial Resistance Laboratory; Brazil.
dc.description.filFil: Lopez-Rojas, Rafael. Hospital Universitario Virgen Macarena. Clinical Unit for Infectious Diseases, Microbiology and Preventive Medicine; Spain.
dc.description.filFil: Lopez-Rojas, Rafael. University of Seville. Department of Microbiology and Medicine; Spain.
dc.description.filFil: Lopez-Rojas, Rafael. Instituto de Biomedicina de Sevilla (IBIS); España.
dc.description.filFil: Trastoy, Rocío. University of A Coruña (UDC). Hospital A Coruña (CHUAC). Microbiology Department-Biomedical Research Institute A Coruña (INIBIC); Spain.
dc.description.filFil: López. María. University of A Coruña (UDC). Hospital A Coruña (CHUAC). Microbiology Department-Biomedical Research Institute A Coruña (INIBIC); Spain.
dc.description.filFil: Bou, Germán. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Centro de Estudios Fotosintéticos y Bioquímicos (CEFOBI -CONICET); Argentina.
dc.description.filFil: Tomás, María. University of A Coruña (UDC). Hospital A Coruña (CHUAC). Microbiology Department-Biomedical Research Institute A Coruña (INIBIC); Spain.
dc.description.filFil: Mussi, María Alejandra. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Centro de Estudios Fotosintéticos y Bioquímicos (CEFOBI -CONICET); Argentina.
dc.description.sponsorshipState Plan for R+D+I 2013–2016 (National Plan for Scientific Research, Technological Development and Innovation 2008–2011): grant PI16/01163es
dc.description.sponsorshipInstituto de Salud Carlos III (ISIII) - European Regional Development Fund “A way of Making Europe” - Fondo Europeo de Desarrollo Regional (FEDER) - Red Española de Investigación en Patología Infecciosa (REIPI): RD16/0016/0001, RD16/0016/0006 y RD16/0016/0008es
dc.description.sponsorshipServicio Gallego de Salud (SERGAS) - Instituto de Salud Carlos III (ISIII): Miguel Servet Research Programes
dc.description.sponsorshipXunta de Galiciaes
dc.description.sponsorshipCoordenação de aperfeiçoamento de pessoal de nivel superior (CAPES): PDSE 99999.001069/2014-04es
dc.description.sponsorshipAgencia Nacional de Promoción Científica y Tecnológica (ANPCyT): PICT 2014-1161es
dc.description.sponsorshipAgencia Santafesina de Ciencia, Tecnología e Innovación (ASACTEI): 2010-147-16es
dc.formatapplication/pdf
dc.format.extent1-17
dc.identifier.issn1664-302X
dc.identifier.urihttp://hdl.handle.net/2133/20088
dc.language.isoenges
dc.publisherFrontiers Mediaes
dc.relation.publisherversionhttps://doi.org/10.3389/fmicb.2019.01376es
dc.relation.publisherversionhttps://www.frontiersin.org/articles/10.3389/fmicb.2019.01376/fulles
dc.rightsopenAccesses
dc.rights.holderUniversidad Nacional de Rosarioes
dc.rights.holderTuttobene, Marisel Rominaes
dc.rights.holderFernández-García, Lauraes
dc.rights.holderBlasco, Lucíaes
dc.rights.holderCribb, Pamelaes
dc.rights.holderAmbroa, Antones
dc.rights.holderMüller, Gabriela Leticiaes
dc.rights.holderFernández-Cuenca, Felipees
dc.rights.holderBleriot, Inéses
dc.rights.holderRodríguez, Ramiro Estebanes
dc.rights.holderBarbosa, Beatriz G. V.es
dc.rights.holderLopez-Rojas, Rafaeles
dc.rights.holderTrastoy, Rocíoes
dc.rights.holderLópez. Maríaes
dc.rights.holderBou, Germánes
dc.rights.holderTomás, Maríaes
dc.rights.holderMussi, María Alejandraes
dc.rights.textAttribution 4.0 International (CC BY 4.0)es
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/*
dc.subjectAcetoines
dc.subjectBlsAes
dc.subjectAcoNes
dc.subjectLightes
dc.subjectAcinetobacteres
dc.titleQuorum and light signals modulate acetoin/butanediol catabolism in Acinetobacter sppes
dc.typepublishedVersion

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