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Ítem Acceso Abierto Acute diarrhoea in children: determination of duration using a combined bismuth hydroxide gel and oral rehydration solution therapy vs. oral rehydration solution(MDPI, 2016-12-21) Oviedo, Adriana; Díaz, Mirna; Valenzuela, María Laura; Vidal, Victoria; Racca, Liliana; Bottai, Hebe; Priore, Graciela; Peluffo, Graciela; Di Bartolomeo, Susana; Cabral, Graciela; Toca, María del CarmenOral rehydration salt (ORS) treatment in young children with acute diarrhoea (AD) has contributed to decrease mortality associated with dehydration although effective strategies to reduce morbidity associated with this disease are required. The aim of this study was to evaluate the diarrhoea duration when using combined colloidal bismuth hydroxide gel (CBHG) and oral rehydration salt treatment compared with ORS therapy in children with AD. We designed a double-blind, randomised prospective study with treatment and control groups. Patients aged one to 12 years, with no prior pathology and with AD of less than 48 h were included. The Chi-squared and Mann-Whitney tests were used, as well as the Cox proportional hazards model and the Kaplan-Meier estimator. Patients were randomised into an ORS and CBHG treatment group and a control group for ORS plus placebo. (Average age: 3.2 years). The result of the post-treatment evaluation with respect to the average duration of AD was 25.5 h for the treated group vs. 41.5 h for the control group (p = 0.015). The average number of stools was 4.8 in the treated group and 8.2 in the control group (p = 0.032). We conclude that the use of CBHG plus ORS significantly reduced the duration of AD, the number of stools and the percentage of children with persistent AD after 24 h of treatment compared to the control group. AD remitted almost twice as fast in patients treated with CBHG and ORS compared to those who received ORS plus placebo.Ítem Acceso Abierto Análisis de la prescripción de medicamentos en una comunidad geriátrica Argentina(Sociedad Médica de Santiago, 2013-02) Marzi, Marta Mónica; Diruscio, Valeriana Alejandra; Núñez, Mariano H.; Pires, Miryam Susana; Quaglia, Nora BeatrízBackground: Although polypharmacy may bejustified in elderly patients with multiple diseases, it may be dangerous, especially when it includes potentially inappropriate medications (PIM). Aim: To identify inappropriate medication and factors associated with the most relevant prescriptions among older people. Material and Methods: Cross-sectional observational analysis of drugs prescribed during the first trimester of 2010 to 179 older adults aged 77 ± 8 years (98 women), living in a geriatric reference hospital in Argentina. The use of potentially inappropriate medications (PIM) in elderly patients was analyzed using Beers Criteria updated to 2012. Results: The mean number of drugs prescribed per individual was 6.1 ± 2.7. The most commonly used drugs were anti-ulcer agents (58.1%), agents acting on the renin-angiotensin system (54.2%), antithrombotic medications (50.8%) and benzodiazepines (50.8 %). The use of antacids and anti-ulcer agents, psychotropic drugs and PIM was significantly higher among patients using six or more drugs daily, compared to the less medicated group (odds ratio (OR) = 6.8, 95% confidence intervals (CI) 3.5-13.2; OR=15.0, 95%CI 5.9-38.4; OR=5.0; 95%IC 2.6-9.8, respectively). Thirty one percent of participants using non-steroidal anti-inflammatory drugs, were not receiving medications for gastric protection. One to four drugs included in the Beers list were prescribed to 66% of participants. Conclusions: Despite the high prevalence of use of antacids and anti-ulcer agents, these drugs were not prescribed to a significant proportion of patients using non-steroidal anti-inflammatory drugs. Strategies to optimize pharmacotherapy in the elderly population are urgently required.Ítem Acceso Abierto ¿Es necesario tener conocimiento avanzados de estadística para acceder a las publicaciones medicas?(Fundación Revista Medicina, 2019-12) Chiapella, Luciana Carla; Lazzarini, Cecilia Leonor; Montenegro, Silvana MarisaÍtem Acceso Abierto Efectos adversos cardíacos de la domperidona en pacientes adultos : revisión sistemática(Sociedad Médica de Santiago, 2015-01) Marzi, Marta Mónica; Weitz, Darío; Avila, Aylén; Molina, Gabriel; Caraballo, Lucía; Piskulic, LauraÍtem Acceso Abierto Revisión sistemática de la evidencia de efectos proarrítmicos de domperidona en infantes(Sociedad Española de Farmacia Hospitalaria, 2014-09) Caraballo, Lucía; Molina, Gabriel; Weitz, Darío; Piskulic, Laura; Avila, Aylén; Marzi, Marta MónicaÍtem Acceso Abierto Identificación y descripción epidemiológica de artículos de revisión de efectos adversos en la atención sanitaria publicados en idioma español(Facultad de Ciencias Médicas, Universidad Nacional de Córdoba, 2016) Weitz, Darío; Avila, Aylén; Molina, Gabriel; Piskulic, Laura; Allasia, María Belén; Caraballo, Lucía; Díaz Pacífico, Fernando; Quaglia, Nora Beatríz; Marzi, Marta Mónica