Update on the biological relevance of lysine acetylation as a novel drug target in trypanosomatids
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Bentham Science Publishers
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The number of acetylated proteins identified from bacteria to mammals has grown
exponentially in the last ten years and it is now accepted that acetylation is a key component in most
eukaryotic signaling pathways, as important as phosphorylation. The enzymes involved in this process
are well described in mammals; acetyltransferases and deacetylases are found inside and outside the
nuclear compartment and have different regulatory functions. In trypanosomatids several of these
enzymes have been described and are postulated to be novel antiparasitic targets for the rational design
of drugs. In this review article we present an update of the most important known acetylated proteins in
trypanosomatids analyzing the acetylomes available. Also, we summarize the information available
regarding acetyltransferases and deacetylases in trypanosomes and their potential use as
chemotherapeutic targets.
"The published manuscript is available at EurekaSelect via https://www.eurekaselect.com/openurl/content.php?genre=article&doi=insert. DOI http://dx.doi.org/10.2174/0929867328666211126145721"
"The published manuscript is available at EurekaSelect via https://www.eurekaselect.com/openurl/content.php?genre=article&doi=insert. DOI http://dx.doi.org/10.2174/0929867328666211126145721"
Palabras clave
Acetylation, Acetyltransferases, Deacetylases, Acetylome, Trypanosomatids, Cytoskeleton