Role of Wnt/beta-catenin pathway in the nucleus accumbens in long-term cocaine-induced neuroplasticity : a possible novel target for addiction treatment

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dc.creator Cuesta, Santiago
dc.creator Batuecas, Jorgelina
dc.creator Severin, Maria Julia
dc.creator Funes, Alejandrina
dc.creator Rosso, Silvana
dc.creator Pacchioni, Alejandra Maria
dc.date.accessioned 2018-02-20T23:24:36Z
dc.date.available 2018-02-20T23:24:36Z
dc.date.issued 2016-12-07
dc.identifier.issn 1471-4159 es
dc.identifier.uri http://hdl.handle.net/2133/10561
dc.description Cocaine addiction is a chronic relapsing disorder characterized by the loss of control over drug-seeking and taking, and continued drug use regardless of adverse consequences. Despite years of research, effective treatments for psycho-stimulant addiction have not been identified. Persistent vulnerability to relapse arises from a number of long-lasting adaptations in the reward circuitry that mediate the enduring response to the drug. Recently, we reported that the activity of the canonical or Wnt/β-catenin pathway in the prefrontal cortex (PFC) is very important in the early stages of cocaine-induced neuroadaptations. In the present work, our main goal was to elucidate the relevance of this pathway in cocaine-induced long-term neuroadaptations that may underlie relapse. We found that a cocaine challenge, after a period of abstinence, induced an increase in the activity of the pathway which is revealed as an increase in the total and nuclear levels of β-catenin (final effector of the pathway) in the nucleus accumbens (NAcc), together with a decrease in the activity of glycogen synthase kinase 3β (GSK3β). Moreover, we found that the pharmacological modulation of the activity of the pathway has long-term effects on the cocaine-induced neuroplasticity at behavioral and molecular levels. All the results imply that changes in the Wnt/β-catenin pathway effectors are long-term neuroadaptations necessary for the behavioral response to cocaine. Even though more research is needed, the present results introduce the Wnt canonical pathway as a possible target to manage cocaine long-term neuroadaptations. es
dc.description.sponsorship Agencia Nacional de Promoción Científica y Tecnológica (ANPCyT), PICT 227-2008 es
dc.format application/pdf
dc.format.extent 114-125 es
dc.language.iso eng es
dc.publisher Wiley es
dc.rights openAccess es
dc.rights.uri https://creativecommons.org/licenses/by-nc/4.0/
dc.subject Nucleus Accumbens es
dc.subject Cocaine es
dc.subject Lithium Chloride es
dc.subject Long-term Neuroadaptations es
dc.subject Sensitization es
dc.title Role of Wnt/beta-catenin pathway in the nucleus accumbens in long-term cocaine-induced neuroplasticity : a possible novel target for addiction treatment es
dc.type article
dc.type artículo
dc.type publishedVersion
dc.rights.holder Wiley es
dc.rights.holder International Society for Neurochemistry es
dc.rights.holder Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas es
dc.rights.holder Cuesta, Santiago es
dc.rights.holder Batuecas, Jorgelina es
dc.rights.holder Severin, Maria Julia es
dc.rights.holder Funes, Alejandrina es
dc.rights.holder Rosso, Silvana B. es
dc.rights.holder Pacchioni, Alejandra María es
dc.relation.publisherversion http://dx.doi.org/doi:10.1111/jnc.13863 es
dc.relation.publisherversion http://onlinelibrary.wiley.com/doi/10.1111/jnc.13863/abstract es
dc.rights.text Attribution-NonCommercial 4.0 International es
dc.citation.title Journal of Neurochemistry es
dc.citation.volume 140(1) es
dc.description.fil Fil: Cuesta, Santiago. Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET); Argentina. es
dc.description.fil Fil: Cuesta, Santiago. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Departamento de Ciencias de los Alimentos y del Medioambiente. Área Toxicología; Argentina. es
dc.description.fil Fil: Batuecas, Jorgelina. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Departamento de Ciencias de los Alimentos y del Medioambiente. Área Toxicología; Argentina. es
dc.description.fil Fil: Severin, María Julia. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Departamento de Ciencias de los Alimentos y del Medioambiente. Área Toxicología; Argentina. es
dc.description.fil Fil: Funes, Alejandrina. Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET); Argentina. es
dc.description.fil Fil: Funes, Alejandrina. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Departamento de Ciencias de los Alimentos y del Medioambiente. Área Toxicología; Argentina. es
dc.description.fil Fil: Rosso, Silvana B. Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET); Argentina. es
dc.description.fil Fil: Rosso, Silvana B. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Departamento de Ciencias de los Alimentos y del Medioambiente. Área Toxicología; Argentina. es
dc.description.fil Fil: Pacchioni, Alejandra María. Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET); Argentina. es
dc.description.fil Fil: Pacchioni, Alejandra María. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Departamento de Ciencias de los Alimentos y del Medioambiente. Área Toxicología; Argentina. es
dc.type.collection articulo
dc.type.version publishedVersion es


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