Effects of 2,4-dichlorophenoxyacetic acid on the ventral prostate of rats during the peri-pubertal, pubertal and adult stage

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dc.citation.titleDrug and Chemical Toxicologyes
dc.creatorPochettino, Arístides A.
dc.creatorHapon, María Belén
dc.creatorBiolatto, Silvana M.
dc.creatorMadariaga, María José
dc.creatorJahn, Graciela A.
dc.creatorKonjuh, Cintia N.
dc.date.accessioned2021-07-07T13:41:33Z
dc.date.available2021-07-07T13:41:33Z
dc.date.issued2016-01
dc.descriptionThe herbicide 2,4-dichlorophenoxyacetic acid (2,4-D) is used on a wide variety of terrestrial and aquatic broadleaf weeds. 2,4-D has been shown to produce a wide range of adverse effects on animal and human health. The aim of the current study was to evaluate the effects of pre- and postnatal exposure to 2,4-D on rat ventral prostate (VP). Pregnant rats were exposed daily to oral doses of 70 mg/kg/day of 2,4-D from 16 days of gestation up to 23 days after delivery. Then, the treated groups (n = 8) were fed with a 2,4-D added diet until sacrificed by decapitation on postnatal day (PND) 45, 60, or 90. Morphometric studies were performed and androgen receptor (AR) protein levels in the VP were determined. AR, insulin-like growth factor-I (IGF-1) and insulin-like growth factor-I receptor (IGF-1R) mRNA expression in the VP along with testosterone (T), dihydroxytestosterone (DHT), growth hormone (GH) and IGF-1 serum levels were also determined to ascertain whether these parameters were differentially affected. Results of this study showed that 2,4-D exposure during gestation and until adulthood altered development of the prostate gland in male rats, delaying it at early ages while increasing its size in adults, indicate that 2,4-D could behave as endocrine disruptors (EDs).es
dc.description.filFil: Pochettino, Arístides A. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Laboratorio de Toxicología Experimental; Argentina.es
dc.description.filFil: Hapon, María Belén. Universidad Nacional de Cuyo. Laboratorio De Reproducción y Lactancia (IMBECU-CONICET); Argentina.es
dc.description.filFil: Biolatto, Silvana M. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Laboratorio de Toxicología Experimental; Argentina.es
dc.description.filFil: Madariaga, María José. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Laboratorio de Toxicología Experimental; Argentina.es
dc.description.filFil: Jahn, Graciela A. Universidad Nacional de Cuyo. Laboratorio De Reproducción y Lactancia (IMBECU-CONICET); Argentina.es
dc.description.filFil: Konjuh, Cintia N. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Laboratorio de Toxicología Experimental; Argentina.es
dc.description.sponsorshipConsejo Nacional de Investigaciones Científicas y Técnicas (CONICET)es
dc.description.sponsorshipAgencia de Promoción Científica y Tecnológica (ANPCyT)es
dc.formatapplication/pdf
dc.format.extent392-399es
dc.identifier.issn1525-6014es
dc.identifier.urihttp://hdl.handle.net/2133/21332
dc.language.isoenges
dc.publisherTaylor and Francises
dc.relation.publisherversionhttps://doi.org/10.3109/01480545.2015.1130718es
dc.rightsopenAccesses
dc.rights.holderTaylor and Francises
dc.rights.holderPochettino, Arístides A.es
dc.rights.holderHapon, María Belénes
dc.rights.holderBiolatto, Silvana M.es
dc.rights.holderMadariaga, María Josées
dc.rights.holderJahn, Graciela A.es
dc.rights.holderKonjuh, Cintia N.es
dc.rights.textAtribución-NoComercial-SinDerivadas 4.0 Internacional (CC BY-NC-ND 4.0)es
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/deed.es*
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/deed.es*
dc.subject2,4-Dichlorophenoxyacetic herbicidees
dc.subjectDevelopmental toxicityes
dc.subjectHormonees
dc.subjectAndrogen receptores
dc.titleEffects of 2,4-dichlorophenoxyacetic acid on the ventral prostate of rats during the peri-pubertal, pubertal and adult stagees
dc.typearticle
dc.typeartículo
dc.typeacceptedVersion
dc.type.collectionarticulo
dc.type.versionacceptedVersiones

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