Expression of the gene encoding secretor type galactoside 2 α fucosyltransferase (FUT2) and ABH antigens in patients with oral lesions

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dc.citation.titleMedicina Oral Patología Oral y Cirugia Bucal
dc.creatorCampi, Carlos
dc.creatorEscovich, Livia
dc.creatorMoreno, Alejandra Soledad
dc.creatorRacca, Liliana
dc.creatorCotorruelo, Carlos
dc.creatorBiondi, Claudia Silvia
dc.date.accessioned2025-03-25T18:19:25Z
dc.date.available2025-03-25T18:19:25Z
dc.date.issued2012
dc.description.abstractObjective: The aim of this work was to evaluate the expression of FUT2 gene in saliva and histo ABH antigens of patients with oral lesions. Study Design: In total 178 subjects were examined, half of whom suffered from oral pre-cancerous and cancerous lesions, while the other half were the healthy control group We analyzed the FUT 2 polymorphism by ASO-PCR (allele specific oligonucleotid – polymerase chain reaction) with specific primers for G428 allele and the wild type allele of FUT2 gene. To reveal A, B and H antigens in tissue sections of the patients (n= 89) we used a modified specific red cell adherence technique. Results: We found a high intensity of oral disease in the non-secretor group (OR = 2.43). A total of 58% of the patients with oral pre-cancerous and cancerous lesions was non secretors (se_/_), in contrast with the healthy population (21.5%). A strongly positive reaction was defined as a sheet of indicator erythrocytes adhered to the epithelial cells. In 31 of the 54 samples analyzed the test showed slightly positive results on atypical areas, and there was a complete antigen deletion in areas affected by neoplasia. Nineteen samples showed a total absence of ABH antigens in both histologically normal and pathological areas. Blood group antigens were expressed at a high level in benign and highly differentiated malignant tumors. In poorly differentiated malignant tumors, they were mostly absent. Conclusion: Considering these results we suggest the use of this method to monitor probable preneoplastic lesions in risk population, especially in those with no secretor status (absence of FUT2 gene).
dc.description.filFil: Campi, Carlos. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Departamento de Bioquímica Clínica. Laboratorio de Inmunohematología Histocompatibilidad e Inmunogenética; Argentina.
dc.description.filFil: Escovich, Livia. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Departamento de Bioquímica Clínica. Laboratorio de Inmunohematología Histocompatibilidad e Inmunogenética; Argentina.
dc.description.filFil: Moreno, Alejandra Soledad. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Departamento de Bioquímica Clínica. Laboratorio de Inmunohematología Histocompatibilidad e Inmunogenética; Argentina.
dc.description.filFil: Racca, Liliana. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Departamento de Bioquímica Clínica. Laboratorio de Inmunohematología Histocompatibilidad e Inmunogenética; Argentina.
dc.description.filFil: Cotorruelo, Carlos. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Departamento de Bioquímica Clínica. Laboratorio de Inmunohematología Histocompatibilidad e Inmunogenética; Argentina.
dc.description.filFil: Biondi, Claudia Silvia. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Departamento de Bioquímica Clínica. Laboratorio de Inmunohematología Histocompatibilidad e Inmunogenética; Argentina.
dc.description.versionpeerreviewed
dc.format.extente63-e68
dc.identifier.citationCampi, C., Escovich, L., Moreno, A., Racca, L., Racca, A., Cotorruelo, C., & Biondi, C. (2012). Expression of the gene encoding secretor type galactoside 2 α fucosyltransferase (FUT2) and ABH antigens in patients with oral lesions. Medicina Oral Patología Oral y Cirugia Bucal, e63–e68. https://doi.org/10.4317/medoral.17239
dc.identifier.issn1698-6946
dc.identifier.urihttps://hdl.handle.net/2133/29110
dc.language.isoen
dc.publisherSociedad Española de Medicina Oral
dc.relation.publisherversionhttp://www.medicinaoral.com/pubmed/medoralv17_i1_p63.pdf
dc.relation.publisherversionhttps://doi.org/10.4317/medoral.17239
dc.rightsopenAccess
dc.rights.holderMedicina Oral S.L.
dc.rights.holderUniversidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectFUT2 gene
dc.subjectABH antigens
dc.subjectSecretor status
dc.subjectOral lesions
dc.titleExpression of the gene encoding secretor type galactoside 2 α fucosyltransferase (FUT2) and ABH antigens in patients with oral lesions
dc.typearticulo
dc.type.collectionarticulo
dc.type.versionpublishedVersion

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