Environmental selection pressures related to iron utilization are involved in the loss of the flavodoxin gene from the plant genome

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dc.citation.titleGenome Biology and Evolutiones
dc.citation.volume7(3)es
dc.creatorPierella Karlusich, Juan J.
dc.creatorCeccoli, Romina Denis
dc.creatorGraña, Martín
dc.creatorRomero, Héctor
dc.creatorCarrillo, Néstor
dc.date.accessioned2021-03-01T15:49:33Z
dc.date.available2021-03-01T15:49:33Z
dc.date.issued2015-02-16
dc.descriptionOxidative stress and iron limitation represent the grim side of life in an oxygen-rich atmosphere. The versatile electron transfer shuttle ferredoxin,aniron-sulfurprotein,isparticularlysensitivetothesehardships,anditsdownregulationunderadverseconditionsseverely compromises survival of phototrophs. Replacement of ferredoxin by a stress-resistant isofunctional carrier, flavin-containing flavodoxin, is a widespread strategy employed by photosynthetic microorganisms to overcome environmental adversities. The flavodoxin gene was lostin the course ofplantevolution, but its reintroduction in transgenicplants confers increased tolerance to environmental stress and iron starvation, raising the question as to whya genetic asset with obvious adaptive value was not kept by natural selection. Phylogenetic analyses reveal that the evolutionary history of flavodoxin is intricate, with several horizontal gene transfer events between distant organisms, including Eukarya, Bacteria, and Archaea. The flavodoxin gene is unevenly distributed in most algal lineages, with flavodoxin-containing species being overrepresented in iron-limited regions and scarce or absent in iron-rich environments. Evaluation of cyanobacterial genomic and metagenomic data yielded essentially the same results, indicating that there was little selection pressure to retain flavodoxin in iron-rich coastal/freshwater phototrophs. Our results show a highly dynamic evolution pattern of flavodoxin tightly connected to the bioavailability of iron. Evidence presented here also indicates that the high concentration of iron in coastal and freshwater habitats may have facilitated the loss of flavodoxin in the freshwater ancestor of modern plants during the transition of photosynthetic organisms from the open oceans to the firm land.es
dc.descriptionThis article has been accepted for publication in Genome Biology and Evolution Published by Oxford University Press.en
dc.description.filFil: Pierella Karlusich, Juan J. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Biología Molecular y Celular de Rosario (IBR -CONICET); Argentina.es
dc.description.filFil: Ceccoli, Romina Denis. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Biología Molecular y Celular de Rosario (IBR -CONICET); Argentina.es
dc.description.filFil: Ceccoli, Romina Denis. Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET); Argentina.es
dc.description.filFil: Graña, Martín. Institut Pasteur. Unidad de Bioinformática; Uruguay.es
dc.description.filFil: Romero, Héctor. Universidad de la República. Facultad de Ciencias/CURE. Departamento de Ecología y Evolución; Uruguay.es
dc.description.filFil: Carrillo, Néstor. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Biología Molecular y Celular de Rosario (IBR -CONICET); Argentina.es
dc.description.sponsorshipAgencia Nacional de Promoción Científica y Tecnológica (ANPCyT): PICT01-14648es
dc.description.sponsorshipMinisterio de Ciencia, Tecnología e Innovación (MINCyT) - Ministerio de Educación y Cultura de la Republica Oriental del Uruguay (MEC): Program of Scientific Cooperation UR/11/06es
dc.formatapplication/pdf
dc.format.extent750-767es
dc.identifier.issn1759-6653es
dc.identifier.urihttp://hdl.handle.net/2133/19954
dc.language.isoenges
dc.publisherOxford University Presses
dc.relation.publisherversionhttps://academic.oup.com/gbe/article/7/3/750/602631es
dc.relation.publisherversionhttps://doi.org/10.1093/gbe/evv031es
dc.rightsopenAccesses
dc.rights.holderUniversidad Nacional de Rosarioes
dc.rights.holderPierella Karlusich, Juan J.es
dc.rights.holderCeccoli, Romina Denises
dc.rights.holderGraña, Martínes
dc.rights.holderRomero, Héctores
dc.rights.holderCarrillo, Néstores
dc.rights.textAttribution 4.0 International (CC BY 4.0)es
dc.rights.urihttp://creativecommons.org/licenses/by/2.5/ar/*
dc.subjectFlavodoxines
dc.subjectFerredoxinses
dc.subjectIrones
dc.subjectPhotosynthesises
dc.subjectCyanobacteriaes
dc.subjectAlgaees
dc.titleEnvironmental selection pressures related to iron utilization are involved in the loss of the flavodoxin gene from the plant genomees
dc.typearticle
dc.typeartículo
dc.typepublishedVersion
dc.type.collectionarticulo
dc.type.versionpublishedVersiones

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