Efectos adversos cardíacos de la domperidona en pacientes adultos : revisión sistemática
dc.citation.title | Revista médica de Chile | es |
dc.citation.volume | 143(1) | es |
dc.creator | Marzi, Marta Mónica | |
dc.creator | Weitz, Darío | |
dc.creator | Avila, Aylén | |
dc.creator | Molina, Gabriel | |
dc.creator | Caraballo, Lucía | |
dc.creator | Piskulic, Laura | |
dc.date.accessioned | 2018-02-14T20:35:27Z | |
dc.date.available | 2018-02-14T20:35:27Z | |
dc.date.issued | 2015-01 | |
dc.description | Background: Domperidone is widely prescribed in patients with gastrointestinal disorders but some cardiac adverse effects have been recently reported. Aim: To evaluate the risk of QT prolongation, ventricular arrhythmias and sudden cardiac death associated with the use of oral domperidone in adults without cancer. Material and Methods: Systematic searches in MEDLINE, LILACS, SciELO, the Cochrane Library and regulatory agencies websites were performed, followed by a manual search of cited references. The search strategy consisted of combining free and indexed text words without any date or language restriction. Results: Three case-control studies met the inclusion criteria; none of them evaluated QT interval prolongation. With low risk of bias, each study quantified the risk of ventricular arrhythmia or sudden cardiac death (VA/SCD). The odds ratios for these events in these studies were 4.7 (95% confidence interval (CI): 1.4-16), 1.59 (95% CI: 1.28-1.98) and 11.02 (95% CI: 2.02-62.3) respectively. A significantly increased risk was observed in patients older than 60 years of age or receiving doses > 30 mg/day. Conclusions: Heterogeneity between selected studies did not allow the computation of a summary measure. However, evidence was found that an increased risk of VA/SCD is associated with the use of oral domperidone in adults. | es |
dc.description.fil | Fil: Marzi, Marta Mónica. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Departamento de Matemática y Estadística; Argentina. | es |
dc.description.fil | Fil: Weitz, Darío. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Departamento de Matemática y Estadística; Argentina. | es |
dc.description.fil | Fil: Avila, Aylén. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Departamento de Matemática y Estadística; Argentina. | es |
dc.description.fil | Fil: Molina, Gabriel. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Departamento de Matemática y Estadística; Argentina. | es |
dc.description.fil | Fil: Caraballo, Lucía. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Departamento de Matemática y Estadística; Argentina. | es |
dc.description.fil | Fil: Piskulic, Laura. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Departamento de Matemática y Estadística; Argentina. | es |
dc.format | application/pdf | |
dc.format.extent | 14-21 | es |
dc.identifier.issn | 0034-9887 | es |
dc.identifier.uri | http://hdl.handle.net/2133/10526 | |
dc.language.iso | spa | es |
dc.publisher | Sociedad Médica de Santiago | es |
dc.relation.publisherversion | http://dx.doi.org/10.4067/S0034-98872015000100002 | es |
dc.relation.publisherversion | http://www.revistamedicadechile.cl/ojs/index.php/rmedica/article/view/3594 | es |
dc.rights | openAccess | es |
dc.rights.holder | Sociedad Médica de Santiago | es |
dc.rights.holder | Universidad Nacional de Rosario | es |
dc.rights.holder | Marzi, Marta Mónica | es |
dc.rights.holder | Weitz, Darío | es |
dc.rights.holder | Avila, Aylén | es |
dc.rights.holder | Molina, Gabriel | es |
dc.rights.holder | Caraballo, Lucía | es |
dc.rights.holder | Piskulic, Laura | es |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-sa/2.5/ar/ | * |
dc.subject | Arrhythmias, Cardiac | es |
dc.subject | Domperidone | es |
dc.subject | Long QT | es |
dc.subject | Review | es |
dc.subject | Arritmias Cardíacas | es |
dc.subject | Domperidona | es |
dc.title | Efectos adversos cardíacos de la domperidona en pacientes adultos : revisión sistemática | es |
dc.type | article | |
dc.type | artículo | |
dc.type | publishedVersion | |
dc.type.collection | articulo | |
dc.type.version | publishedVersion | es |