Role of Heme and Heme-Proteins in Trypanosomatid essential metabolic pathways

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dc.citation.titleEnzyme Researches
dc.citation.volume2011es
dc.creatorTripodi, Karina E. J.
dc.creatorMenendez Bravo, Simón M.
dc.creatorCricco, Julia Alejandra
dc.date.accessioned2020-06-08T16:12:52Z
dc.date.available2020-06-08T16:12:52Z
dc.date.issued2011
dc.descriptionAround the world, trypanosomatids are known for being etiological agents of several highly disabling and often fatal diseases like Chagas disease (Trypanosoma cruzi), leishmaniasis (Leishmania spp.), and African trypanosomiasis (Trypanosoma brucei). Throughout their life cycle, they must cope with diverse environmental conditions, and the mechanisms involved in these processes are crucial for their survival. In this review, we describe the role of heme in several essential metabolic pathways of these protozoans. Notwithstanding trypanosomatids lack of the complete heme biosynthetic pathway, we focus our discussion in the metabolic role played for important heme-proteins, like cytochromes. Although several genes for different types of cytochromes, involved in mitochondrial respiration, polyunsaturated fatty acid metabolism, and sterol biosynthesis, are annotated at the Tritryp Genome Project, the encoded proteins have not yet been deeply studied. We pointed our attention into relevant aspects of these protein functions that are amenable to be considered for rational design of trypanocidal agents.es
dc.description.filFil: Tripodi, Karina E. J. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Departamento de Química Biológica. Instituto de Biología Molecular y Celular de Rosario (IBR-CONICET); Argentina.es
dc.description.filFil: Menendez Bravo, Simón M. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Departamento de Química Biológica. Instituto de Biología Molecular y Celular de Rosario (IBR-CONICET); Argentina.es
dc.description.filFil: Cricco, Julia Alejandra. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Departamento de Química Biológica. Instituto de Biología Molecular y Celular de Rosario (IBR-CONICET); Argentina.es
dc.description.sponsorshipConsejo Nacional de Investigaciones Científicas y Técnicas (CONICET): PIP2010 0685es
dc.formatapplication/pdf
dc.format.extent873230es
dc.identifier.issn2090-0406es
dc.identifier.urihttp://hdl.handle.net/2133/18323
dc.language.isoenges
dc.publisherHindawies
dc.relation.publisherversionhttps://doi.org/10.4061/2011/873230es
dc.relation.publisherversionhttps://www.hindawi.com/journals/er/2011/873230/#acknowledgmentses
dc.rightsopenAccesses
dc.rights.holderTripodi, Karina E. J.es
dc.rights.holderMenendez Bravo, Simón M.es
dc.rights.holderCricco, Julia Alejandraes
dc.rights.holderUniversidad Nacional de Rosarioes
dc.rights.textAttribution 4.0 International (CC BY 4.0)es
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/*
dc.subjectHeme-Proteinses
dc.subjectChagas diseasees
dc.subjectTrypanosoma cruzies
dc.subjectTrypanosomatidses
dc.subjectHeme Biosynthesises
dc.titleRole of Heme and Heme-Proteins in Trypanosomatid essential metabolic pathwayses
dc.typearticle
dc.typeartículo
dc.typepublishedVersion
dc.type.collectionarticulo
dc.type.versionpublishedVersiones

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