Synthesis, Bioevaluation and Structural Study of Substituted Phthalazin-1(2H)-ones Acting as Antifungal Agents
| dc.contributor.author | Derita, Marcos Gabriel | |
| dc.contributor.author | Del Olmo, Esther | |
| dc.contributor.author | Barboza, Bianca | |
| dc.contributor.author | García Cadenas, Ana E. | |
| dc.contributor.author | López Pérez, José L. | |
| dc.contributor.author | Andújar, Sebastián | |
| dc.contributor.author | Enriz, Ricardo Daniel | |
| dc.contributor.author | Zacchino, Susana | |
| dc.contributor.author | San Feliciano, Arturo | |
| dc.date.accessioned | 2013-05-29T20:43:01Z | |
| dc.date.available | 2013-05-29T20:43:01Z | |
| dc.date.issued | 2013-03 | |
| dc.description.abstract | Twenty-five polysubstituted phthalazinone derivatives were synthesized and tested for their antifungal activity against a panel of pathogenic and clinically important yeasts and filamentous fungi. Among them, the compound 4-(4-chlorobenzyl)-2- methylphthalazin-1(2H)-one (5) exhibited a remarkable antifungal activity against standardised strains of dermatophytes and Cryptococcus neoformans, as well as against some clinical isolates. A physicochemical study performed on compound 5 revealed its conformational and electronic characteristics, providing us with useful data for the future design of novel related antifungal analogues. | es |
| dc.description.affiliation | Fil: Derita, Marcos Gabriel. Universidad Nacional de Rosario, Facultad de Farmacia y Bioquímica; Argentina. | |
| dc.description.peerreviewed | Peer reviewed | es |
| dc.identifier.citation | Derita M, del Olmo E, Barboza B, García-Cadenas AE, López-Pérez JL, Andújar S, Enriz D, Zacchino S, San Feliciano A. Synthesis, Bioevaluation and Structural Study of Substituted Phthalazin-1(2H)-ones Acting as Antifungal Agents. Molecules. 2013; 18(3):3479-3501. | es |
| dc.identifier.issn | 1420-3049 | |
| dc.identifier.uri | http://hdl.handle.net/2133/2584 | |
| dc.language.iso | en | es |
| dc.publisher | MDPI Open Access Publishing | es |
| dc.relation.publisherversion | http://www.mdpi.com/1420-3049/18/3/3479 | es |
| dc.rights | openAccess | es |
| dc.rights | Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/) | |
| dc.rights.text | © 2013 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). | es |
| dc.subject | benzylphthalazinones | es |
| dc.subject | antifungal | es |
| dc.subject | Cryptococcus neoformans | es |
| dc.subject | dermatophytes structure–activity relationships | es |
| dc.subject | conformational study | es |
| dc.title | Synthesis, Bioevaluation and Structural Study of Substituted Phthalazin-1(2H)-ones Acting as Antifungal Agents | es |
| dc.type | article | es |
| dc.type | artículo | |
| dc.type | publishedVersion |