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Phosphatidylcholine restores neuronal plasticity of neural stem cells under inflammatory stress

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dc.citation.titleScientific Reportses
dc.citation.volume11
dc.creatorMagaquian, Dario
dc.creatorDelgado Ocaña, Susana
dc.creatorPerez, Consuelo
dc.creatorBanchio, Claudia
dc.date.accessioned2022-05-16T13:03:12Z
dc.date.available2022-05-16T13:03:12Z
dc.date.issued2021-11-24
dc.descriptionThe balances between NSCs growth and differentiation, and between glial and neuronal differentiation play a key role in brain regeneration after any pathological conditions. It is well known that the nervous tissue shows a poor recovery after injury due to the factors present in the wounded microenvironment, particularly inflammatory factors, that prevent neuronal differentiation. Thus, it is essential to generate a favourable condition for NSCs and conduct them to differentiate towards functional neurons. Here, we show that neuroinflammation has no effect on NSCs proliferation but induces an aberrant neuronal differentiation that gives rise to dystrophic, non-functional neurons. This is perhaps the initial step of brain failure associated to many neurological disorders. Interestingly, we demonstrate that phosphatidylcholine (PtdCho)-enriched media enhances neuronal differentiation even under inflammatory stress by modifying the commitment of post-mitotic cells. The proneurogenic effect of PtdCho increases the population of healthy normal neurons. In addition, we provide evidences that this phospholipid ameliorates the damage of neurons and, in consequence, modulates neuronal plasticity. These results contribute to our understanding of NSCs behaviour under inflammatory conditions, opening up new venues to improve neurogenic capacity in the brain.es
dc.description.filFil: Magaquian, Dario. Universidad de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Departamento de Ciencias Biológicas. Instituto de Biología Molecular y Celular de Rosario (IBR-CONICET); Argentina.es
dc.description.filFil: Delgado Ocaña, Susana. Universidad de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Departamento de Ciencias Biológicas. Instituto de Biología Molecular y Celular de Rosario (IBR-CONICET); Argentina.es
dc.description.filFil: Perez, Consuelo. Universidad de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Departamento de Ciencias Biológicas. Instituto de Biología Molecular y Celular de Rosario (IBR-CONICET); Argentina.es
dc.description.filFil: Banchio, Claudia. Universidad de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Departamento de Ciencias Biológicas. Instituto de Biología Molecular y Celular de Rosario (IBR-CONICET); Argentina.es
dc.description.sponsorshipConsejo Nacional de Investigaciones Científicas y Técnicas (CONICET)
dc.description.sponsorshipAgencia Nacional de Promoción Científica y Tecnológica (ANPCyT): PICT 2015-0123, PICT 2017-0167
dc.formatapplication/pdf
dc.format.extent1-12es
dc.identifier.issn2045-2322es
dc.identifier.urihttp://hdl.handle.net/2133/23638
dc.language.isoenges
dc.publisherNature Researches
dc.relation.publisherversionhttps://doi.org/10.1038/s41598-021-02361-5
dc.relation.publisherversionhttps://www.nature.com/articles/s41598-021-02361-5
dc.rightsopenAccesses
dc.rights.holderMagaquian, Darioes
dc.rights.holderDelgado Ocaña, Susanaes
dc.rights.holderPerez, Consueloes
dc.rights.holderBanchio, Claudiaes
dc.rights.textAttribution 4.0 International (CC BY 4.0)es
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/*
dc.subjectCell Plasticityes
dc.subjectNeural Stem Cellses
dc.subjectInflammation Mediatorses
dc.subjectPhosphatidylcholineses
dc.subjectNeuroinflammatory Diseaseses
dc.titlePhosphatidylcholine restores neuronal plasticity of neural stem cells under inflammatory stresses
dc.typepublishedVersion
dc.typearticle
dc.typeartículo
dc.type.collectionarticulo
dc.type.versionpublishedVersion

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