Extracellular vesicles and cancer multidrug resistance: undesirable Intercellular messengers?

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dc.citation.titleLifees
dc.citation.volume13es
dc.creatorBucci Muñoz, María
dc.creatorGola, Aldana Magalí
dc.creatorRigalli, Juan Pablo
dc.creatorCeballos Mancini, María Paula
dc.creatorRuiz, María Laura
dc.date.accessioned2023-09-07T17:35:16Z
dc.date.available2023-09-07T17:35:16Z
dc.date.issued2023-07-27
dc.descriptionCancer multidrug resistance (MDR) is one of the main mechanisms contributing to therapy failure and mortality. Overexpression of drug transporters of the ABC family (ATP-binding cassette) is a major cause of MDR. Extracellular vesicles (EVs) are nanoparticles released by most cells of the organism involved in cell–cell communication. Their cargo mainly comprises, proteins, nucleic acids, and lipids, which are transferred from a donor cell to a target cell and lead to phenotypical changes. In this article, we review the scientific evidence addressing the regulation of ABC transporters by EV-mediated cell–cell communication. MDR transfer from drug-resistant to drug-sensitive cells has been identified in several tumor entities. This was attributed, in some cases, to the direct shuttle of transporter molecules or its coding mRNA between cells. Also, EV-mediated transport of regulatory proteins (e.g., transcription factors) and noncoding RNAs have been indicated to induce MDR. Conversely, the transfer of a drug-sensitive phenotype via EVs has also been reported. Additionally, interactions between non-tumor cells and the tumor cells with an impact on MDR are presented. Finally, we highlight uninvestigated aspects and possible approaches to exploiting this knowledge toward the identification of druggable processes and molecules and, ultimately, the development of novel therapeutic strategies.es
dc.description.filFil: Bucci Muñoz, María. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Fisiología Experimental (IFISE-CONICET); Argentina.es
dc.description.filFil: Gola, Aldana Magalí. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Fisiología Experimental (IFISE-CONICET); Argentina.es
dc.description.filFil: Rigalli, Juan Pablo. Heidelberg University Hospital. Department of Clinical Pharmacology and Pharmacoepidemiology; Germany.es
dc.description.filFil: Ceballos Mancini, María Paula. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Fisiología Experimental (IFISE-CONICET); Argentina.es
dc.description.filFil: Ruiz, María Laura. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Fisiología Experimental (IFISE-CONICET); Argentina.es
dc.description.sponsorshipHorizon 2020 Framework Programme (H2020): 101028473
dc.description.sponsorshipGerman Research Foundation (DFG): RI-2673/2
dc.description.sponsorshipConsejo Nacional de Investigaciones Científicas y Técnicas (CONICET): PIP 2020-0386
dc.description.sponsorshipAgencia Nacional de Promoción Científica y Tecnológica (ANPCyT): PICT 2019-01837
dc.formatapplication/pdf
dc.format.extent1-33es
dc.identifier.issn2075-1729es
dc.identifier.urihttp://hdl.handle.net/2133/26258
dc.language.isoenges
dc.publisherMultidisciplinary Digital Publishing Institute (MDPI)es
dc.relation.publisherversionhttps://doi.org/10.3390/life13081633
dc.relation.publisherversionhttps://www.mdpi.com/2075-1729/13/8/1633
dc.rightsopenAccesses
dc.rights.holderBucci Muñoz, Maríaes
dc.rights.holderGola, Aldana Magalíes
dc.rights.holderRigalli, Juan Pabloes
dc.rights.holderCeballos Mancini, María Paulaes
dc.rights.holderRuiz, María Lauraes
dc.rights.holderUniversidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas
dc.rights.textAttribution 4.0 International (CC BY 4.0)es
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/*
dc.subjectABC transporterses
dc.subjectBreast cancer resistance proteines
dc.subjectDrug resistancees
dc.subjectExtracellular vesicleses
dc.subjectMultidrug resistance associated proteines
dc.subjectP-glycoproteines
dc.titleExtracellular vesicles and cancer multidrug resistance: undesirable Intercellular messengers?es
dc.typearticle
dc.typeartículo
dc.typepublishedVersion
dc.type.collectionarticulo
dc.type.versionpublishedVersiones

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