Physical-mathematical model to predict the kinetic coagulation process by clotting activity of bacterial endopeptidases

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dc.citation.titlePharmacy & Pharmacology International Journales
dc.creatorMancilla Canales, Manuel Arturo
dc.creatorFolmer Côrrea, Ana Paula
dc.creatorRiquelme, Bibiana Doris
dc.creatorBrandelli, Adriano
dc.creatorRisso, Patricia Hilda
dc.date.accessioned2022-12-01T16:30:01Z
dc.date.available2022-12-01T16:30:01Z
dc.date.issued2022-08
dc.descriptionA physical-mathematical model was used to evaluate the capability of an enzymatic pool of Bacillus sp. P7 (isolated from Piaractus mesopotamicus) to promote the bovine casein micelles coagulation. Experiments were designed to assess the effects of temperature, pH, and enzyme activity/mass of substrate ratio on the kinetic parameters of the coagulation process and the microstructure of the obtained clots. Descriptive and predictive equations indicate that the temperature and the pH modified these parameters significantly. In optimal conditions, the clot’s mean pore size was 3.6 times smaller using chymosin. On the other hand, rheological measurements evidence a moderate elasticity of clot, which indicates the usefulness of P7 protease preparation as a clotting agent in spreadable or soft cheese manufacture. Also, the hydrolysis products, which are in the whey after casein micelles coagulation, demonstrated antioxidant activities. Equations to model and predict the process kinetics were combined with rheological and microstructure analyses of the obtained clots, and whey bioactivities were evaluated. Nevertheless, the use of P7PP requires further investigation concerning the stability of the enzyme preparation during storage, its performance, and how these variables could be related to the proposed models.es
dc.description.filFil: Mancilla Canales, Manuel Arturo. Grupo de Física Biomédica. Instituto de Física Rosario (CONICET-UNR); Argentina.es
dc.description.filFil: Mancilla Canales, Manuel Arturo. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas; Argentina.es
dc.description.filFil: Folmer Côrrea, Ana Paula. Universidade Federal de Rio Grande do Sul. Instituto de Ciência e Tecnologia de Alimentos; Brasil.es
dc.description.filFil: Riquelme, Bibiana Doris. Grupo de Física Biomédica. Instituto de Física Rosario (CONICET-UNR); Argentina.es
dc.description.filFil: Riquelme, Bibiana Doris. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas; Argentina.es
dc.description.filFil: Brandelli, Adriano. Universidade Federal de Rio Grande do Sul. Instituto de Ciência e Tecnologia de Alimentos; Brasil.es
dc.description.filFil: Risso, Patricia Hilda. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas; Argentina.es
dc.description.filFil: Risso, Patricia Hilda. Universidad Nacional de Rosario. Facultad de Ciencias Veterinarias; Argentina.es
dc.description.sponsorshipUniversidad Nacional de Rosario
dc.description.sponsorshipAgencia Nacional de Promoción Científica y Tecnológica: PICT-2011-1354
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipMinisterio de Ciencia, Tecnología e Innovación Productiva (MINCyT)
dc.formatapplication/pdf
dc.format.extent130-135es
dc.identifier.issn2379-6367es
dc.identifier.urihttp://hdl.handle.net/2133/24936
dc.language.isoenges
dc.publisherMedCravees
dc.relation.publisherversionhttps://medcraveonline.com/PPIJ/PPIJ-10-00375.pdf
dc.relation.publisherversionhttps://doi.org/10.15406/ppij.2022.10.00375
dc.rightsopenAccesses
dc.rights.holderMancilla Canales, Manuel Arturoes
dc.rights.holderFolmer Côrrea, Ana Paulaes
dc.rights.holderRiquelme, Bibiana Dorises
dc.rights.holderBrandelli, Adrianoes
dc.rights.holderRisso, Patricia Hildaes
dc.rights.textAtribución-NoComercial 4.0 Internacional (CC BY-NC 4.0)es
dc.rights.urihttps://creativecommons.org/licenses/by-nc/4.0/
dc.subjectBacillus sp. P7es
dc.subjectBovine casein micellees
dc.subjectEnzymatic coagulationes
dc.subjectExperimental designes
dc.subjectAntioxidant activityes
dc.titlePhysical-mathematical model to predict the kinetic coagulation process by clotting activity of bacterial endopeptidaseses
dc.typearticle
dc.typeartículo
dc.typepublishedVersion
dc.type.collectionarticulo
dc.type.versionpublishedVersiones

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