Assessing endocrine and immune parameters in human immunodeficiency virus-infected patients before and after the immune reconstitution inflammatory syndrome

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dc.citation.titleArchives of Endocrinology and Metabolism
dc.creatorRateni, Liliana Beatriz
dc.creatorLupo, Sergio
dc.creatorRacca, Liliana
dc.creatorPalazzi, Jorge
dc.creatorGhersevich, Sergio
dc.date.accessioned2024-09-06T15:55:35Z
dc.date.available2024-09-06T15:55:35Z
dc.date.issued2018-02
dc.description.abstractObjective: The present study compares immune and endocrine parameters between HIV-infected patients who underwent the Immune Reconstitution Inflammatory Syndrome (IRIS-P) during antiretroviral therapy (ART) and HIV-patients who did not undergo the syndrome (non-IRIS-P). Materials and methods: Blood samples were obtained from 31 HIV-infected patients (15 IRIS-P and 16 non-IRIS-P) before ART (BT) and 48 ± 2 weeks after treatment initiation (AT). Plasma Interleukin-6 (IL-6) and Interleukin-18 (IL-18) were determined by ELISA. Cortisol, dehydroepiandrosterone sulfate (DHEA-S) and thyroxin concentrations were measured using chemiluminescence immune methods. Results: Concentrations of IL-6 (7.9 ± 1.9 pg/mL) and IL-18 (951.5 ± 233.0 pg/mL) were significantly higher (p < 0.05) in IRIS-P than in non-IRIS-P (3.9 ± 1.0 pg/mL and 461.0 ± 84.4 pg/mL, respectively) BT. Mean T4 plasma level significantly decreased in both groups of patients after treatment (p < 0.05). In both groups cortisol levels were similar before and after ART (p > 0.05). Levels of DHEA-S in IRIS-P decreased AT (1080.5 ± 124.2 vs. 782.5 ± 123.8 ng/mL, p < 0.05) and they were significantly lower than in non-IRIS-P (782.5 ± 123.8 vs. 1203.7 ± 144.0 ng/mL, p < 0.05). IRIS-P showed higher values of IL-6 and IL-18 BT and lower levels of DHEA-S AT than in non-IRIS-P. Conclusion: These parameters could contribute to differentiate IRIS-P from non-IRIS-P. The significant decrease in DHEA-S levels in IRIS-P after ART might suggest a different adrenal response
dc.description.filFil: Rateni, Liliana Beatriz. Universidad Nacional de Rosario. Facultad de Ciencias Médicas; Argentina.
dc.description.filFil: Lupo, Sergio. Universidad Nacional de Rosario. Facultad de Ciencias Médicas; Argentina.
dc.description.filFil: Lupo, Sergio. Center for Assistance and Comprehensive Clinical Research (CAICI); Argentina.
dc.description.filFil: Racca, Liliana. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas; Argentina.
dc.description.filFil: Palazzi, Jorge. Center for Assistance and Comprehensive Clinical Research (CAICI); Argentina.
dc.description.filFil: Ghersevich, Sergio. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas; Argentina.
dc.description.sponsorshipFogarty International Center
dc.format.extent64-71
dc.identifier.issn2359-4292
dc.identifier.urihttps://hdl.handle.net/2133/27736
dc.language.isoen
dc.publisherBrazilian Society of Endocrinology and Metabolism
dc.relation.publisherversionhttps://doi.org/10.20945/2359-3997000000010
dc.relation.publisherversionhttps://www.scielo.br/j/aem/a/GBwjFKLvMDFppzXdPgRThCw/?lang=en
dc.rightsopenAccess
dc.rights.holderArchives of Endocrinology and Metabolism
dc.rights.holderUniversidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas
dc.rights.textAttribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectHIV
dc.subjectInterleukins
dc.subjectImmune reconstitution syndrome
dc.subjectCortisol
dc.subjectDehydroepiandrosterone sulfate
dc.titleAssessing endocrine and immune parameters in human immunodeficiency virus-infected patients before and after the immune reconstitution inflammatory syndrome
dc.typearticulo
dc.type.collectionarticulo
dc.type.versionpublishedVersion

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