Liquid chromatography with diode array detection and multivariate curve resolution for the selective and sensitive quantification of estrogens in natural waters.

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dc.citation.titleAnalytica Chimica Actaen
dc.citation.volume835en
dc.creatorPérez, Rocío Laura
dc.creatorEscandar, Graciela Mónica
dc.date.accessioned2018-06-14T12:44:22Z
dc.date.available2018-06-14T12:44:22Z
dc.date.issued2014-05-17
dc.descriptionFollowing the green analytical chemistry principles, an efficient strategy involving second-order data provided by liquid chromatography (LC) with diode array detection (DAD) was applied for the simultaneous determination of estriol, 17β-estradiol, 17α-ethinylestradiol and estrone in natural water samples. After a simple pre-concentration step, LC-DAD matrix data were rapidly obtained (in less than 5 min) with a chromatographic system operating isocratically. Applying a second-order calibration algorithm based on multivariate curve resolution with alternating least-squares (MCR-ALS), successful resolution was achieved in the presence of sample constituents that strongly coelute with the analytes. The flexibility of this multivariate model allowed the quantification of the four estrogens in tap, mineral, underground and river water samples. Limits of detection in the range between 3 and 13 ng L−1, and relative prediction errors from 2 to 11% were achieved.es
dc.description.filFil: Pérez, Rocío Laura. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Química Rosario (IQUIR-CONICET); Argentina.es
dc.description.filFil: Escandar, Graciela Mónica. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Química Rosario (IQUIR-CONICET); Argentina.es
dc.description.sponsorshipUniversidad Nacional de Rosarioes
dc.description.sponsorshipConsejo Nacional de Investigaciones Científicas y Técnicas (CONICET)es
dc.description.sponsorshipAgencia Nacional de Promoción Científica y Tecnológica (ANPCyT): Project 2010-0084es
dc.formatapplication/pdf
dc.format.extent19-28en
dc.identifier.issn0003-2670
dc.identifier.urihttp://hdl.handle.net/2133/11453
dc.language.isoenges
dc.publisherElsevieres
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S0003267014006072?via%3Dihubes
dc.relation.publisherversionhttp://dx.doi.org/10.1016/j.aca.2014.05.015es
dc.rightsopenAccesses
dc.rights.holderElsevier Massones
dc.rights.holderUniversidad Nacional de Rosarioes
dc.rights.holderPérez, Rocío Lauraes
dc.rights.holderEscandar, Graciela Mónicaes
dc.rights.textAtribución-NoComercial-SinDerivadas 4.0 Internacional (CC BY-NC-ND 4.0)es
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/deed.es*
dc.subjectEstrogenses
dc.subjectLiquid Chromatographyes
dc.subjectDiode Array Detectiones
dc.subjectMultivariate Curve Resolutiones
dc.subjectNatural Waterses
dc.titleLiquid chromatography with diode array detection and multivariate curve resolution for the selective and sensitive quantification of estrogens in natural waters.es

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