Characterization of sildenafil citrate tablets of different sources by near infrared chemical imaging and chemometric tools

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dc.creatorPoppi, Ronei Jesus
dc.creatorSabin, Guilherme Post
dc.creatorLozano, Valeria Antonella
dc.creatorFortunato de Carvalho Rocha, Werickson
dc.creatorOrtiz, Rafael
dc.creatorRomão, Wanderson
dc.date.accessioned2017-11-30T11:42:33Z
dc.date.available2017-11-30T11:42:33Z
dc.date.issued2013-11
dc.descriptionIn this paper the chemical imaging technique by near infrared spectroscopy was applied for characterization of drug formulations in tablets of sildenafil citrate of different sources. This work is original and has never been published because it was used the sildenafil citrate, including in the commercial one called "Viagra". In the first stage of the study, a chemometric method based on multivariate curve resolution was properly chosen for the development of the distribution map of concentrations of the active ingredient in tablets. In the second step, the normalized histograms of images from active ingredient were classified by hierarchical cluster analysis. Finally it was possible to recognize the patterns of homogeneity of images in sildenafil citrate tablet. This concept can be used to improve the knowledge of industrial products and processes, as well as, for characterization of counterfeit drugs.es
dc.description.sponsorshipFapespes
dc.description.sponsorshipCNPqes
dc.description.sponsorshipUniversidade Estadual de Campinas. Instituto de Químicaes
dc.formatapplication/pdf
dc.identifier.issn0731-7085
dc.identifier.other1873-264X
dc.identifier.urihttp://hdl.handle.net/2133/9461
dc.language.isoenges
dc.publisherJournal of Pharmaceutical and Biomedical Analysises
dc.relation.publisherversionhttps://doi.org/10.1016/j.jpba.2013.07.036es
dc.relation.publisherversionhttp://www.sciencedirect.com/science/article/pii/S0731708513003427?via%3Dihubes
dc.rightsopenAccesses
dc.rights.holderElsevieres
dc.rights.holderSabin, Guilherme P.es
dc.rights.holderLozano, Valeria A.es
dc.rights.holderRocha, Werickson F. C.es
dc.rights.holderRomão, Wandersones
dc.rights.holderOrtiz, Rafael S.es
dc.rights.holderPoppi, Ronei Jes
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/2.5/ar/*
dc.subjectSildenafil citratees
dc.subjectChemical imaginges
dc.subjectNear infrared spectroscopyes
dc.subjectMultivariate curve resolutiones
dc.subjectClassificationes
dc.subjectRecognize the patternses
dc.titleCharacterization of sildenafil citrate tablets of different sources by near infrared chemical imaging and chemometric toolses

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