Zanthosimuline and Related Pyranoquinolines as Antifungal Agents for Postharvest Fruit Disease Control

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dc.citation.titleACS Omegaes
dc.citation.volume5es
dc.creatorDi Liberto, Melina G.
dc.creatorCaldo, Agustín J.
dc.creatorQuiroga, Ariel Darío
dc.creatorRiveira, Martín Jorge
dc.creatorDerita, Marcos Gabriel
dc.date.accessioned2021-08-26T21:10:05Z
dc.date.available2021-08-26T21:10:05Z
dc.date.issued2020
dc.descriptionThe natural product zanthosimuline and its 18 analogues were easily prepared from simple starting materials and evaluated in vitro against postharvest fruit fungal pathogens. The panel included Penicillium digitatum, Botrytis cinerea, Monilinia fructicola, and Rhizopus stolonifer; all of them causing relevant economic losses worldwide. The minimum inhibitory concentrations and minimum fungicidal concentrations of each compound were determined, and the main structure–activity relationships were established. The biological activity observed was strongly increased by maintaining the prenyl side chain of zanthosimuline in an N-demethylated derivative. In addition, the compound that is the most active in the in vitro evaluation was tested in freshly harvested peaches exhibiting a promising brown rot control profile, comparable to the commercial agent carbendazim but demonstrating less toxicity against human liver cell lines.es
dc.description.filFil: Di Liberto, Melina G. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Farmacognosia; Argentina.es
dc.description.filFil: Caldo, Agustín J. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Química Rosario (IQUIR-CONICET); Argentina.es
dc.description.filFil: Quiroga, Ariel D. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Fisiología Experimental (IFISE-CONICET); Argentina.es
dc.description.filFil: Riveira, Martín Jorge. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Química Rosario (IQUIR-CONICET); Argentina.es
dc.description.filFil: Derita, Marcos Gabriel. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Farmacognosia; Argentina.es
dc.description.filFil: Derita, Marcos Gabriel. Universidad Nacional del Litoral. Facultad de Ciencias Agrarias. Instituto de Ciencias Agropecuarias del Litoral (ICiAgro Litoral-CONICET); Argentina.es
dc.description.sponsorshipConsejo Nacional de Investigaciones Científicas y Técnicas (CONICET): PIP No 2015-0524es
dc.description.sponsorshipAgencia Nacional de Promoción Científica y Tecnológica (ANPCyT): PICT No 2015-2259, PICT No 2014-0408, PICT No 2017-2694es
dc.description.sponsorshipAgencia Santafesina de Ciencia, Tecnología e Innovación (ASACTEI): AC - 2015-00005es
dc.description.sponsorshipUniversidad Nacional de Rosario (UNR): BIO580es
dc.formatapplication/pdf
dc.format.extent7481–7487es
dc.identifier.issn2470-1343es
dc.identifier.urihttp://hdl.handle.net/2133/21775
dc.language.isoenges
dc.publisherAmerican Chemical Societyes
dc.relation.publisherversionhttps://pubs.acs.org/doi/10.1021/acsomega.0c00225#es
dc.relation.publisherversionhttps://doi.org/10.1021/acsomega.0c00225es
dc.rightsopenAccesses
dc.rights.holderDi Liberto, Melina G.es
dc.rights.holderCaldo, Agustín J.es
dc.rights.holderQuiroga, Ariel D.es
dc.rights.holderRiveira, Martín Jorgees
dc.rights.holderDerita, Marcos Gabrieles
dc.rights.holderUniversidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas
dc.rights.textAtribución-NoComercial-CompartirIguales
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/2.5/ar/*
dc.subjectInfectious diseaseses
dc.subjectAntimicrobial agentses
dc.subjectReaction productses
dc.subjectSolventses
dc.subjectOrganic compoundses
dc.titleZanthosimuline and Related Pyranoquinolines as Antifungal Agents for Postharvest Fruit Disease Controles
dc.typearticle
dc.typeartículo
dc.typepublishedVersion
dc.type.collectionarticulo
dc.type.versionpublishedVersiones

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