Data of ureagenesis from ammonia, glutamine and alanine, and mitochondrial aquaporin-8 expression in thioacetamide-treated hepatocytes

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dc.citation.titleData in Brief
dc.citation.volume30
dc.creatorCapiglioni, Alejo M.
dc.creatorAlvarez, María de Luján
dc.creatorMarinelli, Raúl A.
dc.date.accessioned2024-05-21T16:38:57Z
dc.date.available2024-05-21T16:38:57Z
dc.date.issued2020-05
dc.description.abstractWe present data about the synthesis of urea from different substrates, i.e., free ammonia, glutamine and alanine in primary cultured rat hepatocytes treated or untreated with the model hepatotoxic agent thioacetamide (TAA). We also provide data about the expression of mitochondrial aquaporin-8 (mtAQP8), a hepatocyte channel protein which facilitates ammonia diffusion into mitochondria to supply the urea cycle. Ammonia-derived ureagenesis was significantly inhibited by about 30% while that from the both amino acids resulted unaffected in TAA-treated hepatocytes. Protein expression of mtAQP8 was decreased by about 80% after TAA treatment. These data can be useful for the understanding of the mechanisms of drug-induced hepatic dysfunction.
dc.description.filFil: Capiglioni, Alejo M. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Fisiología Experimental (CONICET-IFISE); Argentina.
dc.description.filFil: Alvarez, María de Luján. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Fisiología Experimental (CONICET-IFISE); Argentina.
dc.description.filFil: Marinelli, Raúl A. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Fisiología Experimental (CONICET-IFISE); Argentina.
dc.description.sponsorshipConsejo Nacional de Investigaciones Científicas y Tecnológicas (CONICET): PIP 2015-088, PUE 0089
dc.description.sponsorshipAgencia Nacional de Promoción Científica y Tecnológica (ANPCyT): PICT 2015-0439
dc.format.extent1-5
dc.identifier.issn2352-3409
dc.identifier.urihttps://hdl.handle.net/2133/27079
dc.language.isoen
dc.publisherElsevier
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S2352340920305266?via%3Dihub#ack0001
dc.relation.publisherversionhttps://doi.org/10.1016/j.dib.2020.105632
dc.rightsopenAccess
dc.rights.holderCapiglioni, Alejo M.
dc.rights.holderAlvarez, María de Luján
dc.rights.holderMarinelli, Raúl A.
dc.rights.holderUniversidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas
dc.rights.textAttribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectUreagenesis
dc.subjectAmmonia
dc.subjectGlutamine
dc.subjectAlanine
dc.subjectThioacetamide
dc.subjectMitochondrial aquaporin-8
dc.titleData of ureagenesis from ammonia, glutamine and alanine, and mitochondrial aquaporin-8 expression in thioacetamide-treated hepatocytes
dc.typearticulo
dc.type.collectionarticulo
dc.type.versionpublishedVersion

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