Acute diarrhoea in children: determination of duration using a combined bismuth hydroxide gel and oral rehydration solution therapy vs. oral rehydration solution

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dc.citation.titleChildren
dc.citation.volume3
dc.creatorOviedo, Adriana
dc.creatorDíaz, Mirna
dc.creatorValenzuela, María Laura
dc.creatorVidal, Victoria
dc.creatorRacca, Liliana
dc.creatorBottai, Hebe
dc.creatorPriore, Graciela
dc.creatorPeluffo, Graciela
dc.creatorDi Bartolomeo, Susana
dc.creatorCabral, Graciela
dc.creatorToca, María del Carmen
dc.date.accessioned2024-05-31T21:51:24Z
dc.date.available2024-05-31T21:51:24Z
dc.date.issued2016-12-21
dc.description.abstractOral rehydration salt (ORS) treatment in young children with acute diarrhoea (AD) has contributed to decrease mortality associated with dehydration although effective strategies to reduce morbidity associated with this disease are required. The aim of this study was to evaluate the diarrhoea duration when using combined colloidal bismuth hydroxide gel (CBHG) and oral rehydration salt treatment compared with ORS therapy in children with AD. We designed a double-blind, randomised prospective study with treatment and control groups. Patients aged one to 12 years, with no prior pathology and with AD of less than 48 h were included. The Chi-squared and Mann-Whitney tests were used, as well as the Cox proportional hazards model and the Kaplan-Meier estimator. Patients were randomised into an ORS and CBHG treatment group and a control group for ORS plus placebo. (Average age: 3.2 years). The result of the post-treatment evaluation with respect to the average duration of AD was 25.5 h for the treated group vs. 41.5 h for the control group (p = 0.015). The average number of stools was 4.8 in the treated group and 8.2 in the control group (p = 0.032). We conclude that the use of CBHG plus ORS significantly reduced the duration of AD, the number of stools and the percentage of children with persistent AD after 24 h of treatment compared to the control group. AD remitted almost twice as fast in patients treated with CBHG and ORS compared to those who received ORS plus placebo.
dc.description.filFil: Oviedo, Adriana. Hospital Nacional Alejandro Posadas. Servicio de Pediatría. Sección de Gastroenterología; Argentina.
dc.description.filFil: Díaz, Mirna. Hospital Nacional Alejandro Posadas. Servicio de Pediatría. Sección de Gastroenterología; Argentina.
dc.description.filFil: Valenzuela, María Laura. Hospital Nacional Alejandro Posadas. Servicio de Pediatría. Sección de Gastroenterología; Argentina.
dc.description.filFil: Vidal, Victoria. Hospital Nacional Alejandro Posadas. Servicio de Pediatría. Sección de Gastroenterología; Argentina.
dc.description.filFil: Toca, María del Carmen. Hospital Nacional Alejandro Posadas. Servicio de Pediatría. Sección de Gastroenterología; Argentina.
dc.description.filFil: Racca, Liliana. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Área de Estadística y Procesamiento de Datos; Argentina.
dc.description.filFil: Bottai, Hebe. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Área de Estadística y Procesamiento de Datos; Argentina.
dc.description.filFil: Priore, Graciela. Hospital Nacional Alejandro Posadas. Laboratorio Central. Sección de Microbiología; Argentina.
dc.description.filFil: Peluffo, Graciela. Hospital Nacional Alejandro Posadas. Laboratorio Central. Sección de Microbiología; Argentina.
dc.description.filFil: Di Bartolomeo, Susana. Hospital Nacional Alejandro Posadas. Laboratorio Central. Sección de Microbiología; Argentina.
dc.description.filFil: Cabral, Graciela. Hospital Nacional Alejandro Posada. Laboratorio Central. Sección Virología; Argentina.
dc.description.versionpeerreviewed
dc.format.extent1-8
dc.identifier.issn2227-9067
dc.identifier.urihttps://hdl.handle.net/2133/27122
dc.language.isoen
dc.publisherMDPI
dc.relation.publisherversionhttps://doi.org/10.3390/children3040045
dc.relation.publisherversionhttps://www.mdpi.com/2227-9067/3/4/45
dc.rightsopenAccess
dc.rights.holderOviedo, Adriana
dc.rights.holderDíaz, Mirna
dc.rights.holderValenzuela, María Laura
dc.rights.holderVidal, Victoria
dc.rights.holderRacca, Liliana
dc.rights.holderBottai, Hebe
dc.rights.holderPriore, Graciela
dc.rights.holderPeluffo, Graciela
dc.rights.holderDi Bartolomeo, Susana
dc.rights.holderCabral, Graciela
dc.rights.holderToca, María del Carmen
dc.rights.holderUniversidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas
dc.rights.textAttribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectAcute diarrhoea
dc.subjectBismuth hydroxide gel
dc.subjectHydration salts
dc.subjectChildren
dc.subjectDiarrhea, infantile
dc.titleAcute diarrhoea in children: determination of duration using a combined bismuth hydroxide gel and oral rehydration solution therapy vs. oral rehydration solution
dc.typearticulo
dc.type.collectionarticulo
dc.type.versionpublishedVersion

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