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Spectroflurimetric study of estrogen-cyclodextrin inclusion complexes in aqueous systems

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dc.creatorPérez, Rocío Laura
dc.creatorEscandar, Graciela Mónica
dc.date.accessioned2018-11-21T13:33:26Z
dc.date.available2018-11-21T13:33:26Z
dc.date.issued2013-02-21
dc.descriptionFor the first time, the spectrofluorimetric properties of estrone (E1), 17β-estradiol (E2), estriol (E3), and 17α-ethinylestradiol (EE2) are studied in aqueous solutions after the addition of native and derivative cyclodextrins. In contrast to previous reports, the behavior of the systems is analysed in the absence of organic solvents able to modify the guest-host interaction. The significant differences between the obtained association constants with those reported in solvent mixtures are shown and discussed. In order to evaluate the influence of both the estrogen structure and the presence of cyclodextrin substituents in the inclusion phenomena, fluorescent and acid-base behaviors of the systems are compared and discussed. The interaction of estrogens with micellar media formed by selected surfactants is also studied. It is demonstrated that estrogen-cyclodextrin complexes in aqueous solution are useful for improving fluorimetric detection limits and, since cyclodextrins are non-toxic and mitigate most of the solubility problems which require the use of organic solvents, the studied complexes are excellent candidates for extraction, separation, pre-concentration and removal processes maintaining the principles of the green analytical chemistry.es
dc.description.sponsorshipUniversidad Nacional de Rosarioes
dc.description.sponsorshipConsejo Nacional de Investigaciones Científicas y Técnicas (CONICET): Project PIP 1950es
dc.description.sponsorshipAgencia Nacional de Promoción Científica y Tecnológica (ANPCyT): Project PICT 2010-0084es
dc.formatapplication/pdf
dc.identifier.issn0003-2654
dc.identifier.urihttp://hdl.handle.net/2133/13469
dc.language.isoenges
dc.publisherRoyal Society of Chemistryes
dc.relation.publisherversionhttp://dx.doi.org/10.1039/C2AN36395Jes
dc.relation.publisherversionhttps://pubs.rsc.org/en/Content/ArticleLanding/2013/AN/c2an36395j#!divAbstractes
dc.rightsopenAccesses
dc.rights.holderUniversidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticases
dc.rights.holderRoyal Society of Chemistryes
dc.rights.holderPerez, Rocío Lauraes
dc.rights.holderEscandar, Graciela Mónicaes
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/2.5/ar/*
dc.subjectFluorescencees
dc.subjectCyclodextrines
dc.subjectEstrogenses
dc.titleSpectroflurimetric study of estrogen-cyclodextrin inclusion complexes in aqueous systemses

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