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Hepatocyte and sertoli cell aquaporins, recent advances and research trends

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dc.citation.titleInternational Journal of Molecular Scienceses
dc.citation.volume17es
dc.creatorBernardino, Raquel L.
dc.creatorMarinelli, Raúl A.
dc.creatorMaggio, Anna
dc.creatorGena, Patrizia
dc.creatorCataldo, Ilaria
dc.creatorAlves, Marco G.
dc.creatorSvelto, María
dc.creatorOliveira, Pedro F.
dc.creatorCalamita, Giuseppe
dc.date.accessioned2021-03-01T18:48:28Z
dc.date.available2021-03-01T18:48:28Z
dc.date.issued2016-07-09
dc.descriptionAquaporins (AQPs) are proteinaceous channels widespread in nature where they allow facilitated permeation of water and uncharged through cellular membranes. AQPs play a number of important roles in both health and disease. This review focuses on the most recent advances and research trends regarding the expression and modulation, as well as physiological and pathophysiological functions of AQPs in hepatocytes and Sertoli cells (SCs). Besides their involvement in bile formation, hepatocyte AQPs are involved in maintaining energy balance acting in hepatic gluconeogenesis and lipid metabolism, and in critical processes such as ammonia detoxification and mitochondrial output of hydrogen peroxide. Roles are played in clinical disorders including fatty liver disease, diabetes, obesity, cholestasis, hepatic cirrhosis and hepatocarcinoma. In the seminiferous tubules, particularly in SCs, AQPs are also widely expressed and seem to be implicated in the various stages of spermatogenesis. Like in hepatocytes, AQPs may be involved in maintaining energy homeostasis in these cells and have a major role in the metabolic cooperation established in the testicular tissue. Altogether, this information represents the mainstay of current and future investigation in an expanding field.es
dc.descriptionPara citar este articulo: Bernardino, R.L.; Marinelli, R.A.; Maggio, A.; Gena, P.; Cataldo, I.; Alves, M.G.; Svelto, M.; Oliveira, P.F.; Calamita, G. Hepatocyte and Sertoli Cell Aquaporins, Recent Advances and Research Trends. Int. J. Mol. Sci. 2016, 17, 1096. https://doi.org/10.3390/ijms17071096
dc.description.filFil: Bernardino, Raquel L. University of Porto. Institute of Biomedical Sciences Abel Salazar (ICBAS). Unit for Multidisciplinary Research in Biomedicine (UMIB); Portugal.es
dc.description.filFil: Bernardino, Raquel L. University of Porto. Institute of Biomedical Sciences Abel Salazar (ICBAS). Department of Microscopy, Laboratory of Cell Biology; Portugal.es
dc.description.filFil: Marinelli, Raúl A. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Fisiología Experimental (IFISE -CONICET); Argentina.es
dc.description.filFil: Maggio, Anna. University of Bari “Aldo Moro”. Department of Biosciences, Biotechnologies and Biopharnaceutics; Italy.es
dc.description.filFil: Gena, Patrizia. University of Bari “Aldo Moro”. Department of Biosciences, Biotechnologies and Biopharnaceutics; Italy.es
dc.description.filFil: Cataldo, Ilaria. University of Bari “Aldo Moro”. Department of Biosciences, Biotechnologies and Biopharnaceutics; Italy.es
dc.description.filFil: Alves, Marco G. University of Beira Interior. CICS-UBI, Health Sciences Research Centre; Portugal.es
dc.description.filFil: Svelto, María. University of Bari “Aldo Moro”. Department of Biosciences, Biotechnologies and Biopharnaceutics; Italy.es
dc.description.filFil: Oliveira, Pedro F. University of Porto. Institute of Biomedical Sciences Abel Salazar (ICBAS). Unit for Multidisciplinary Research in Biomedicine (UMIB); Portugal.es
dc.description.filFil: Oliveira, Pedro F. University of Porto. Institute of Biomedical Sciences Abel Salazar (ICBAS). Department of Microscopy, Laboratory of Cell Biology; Portugal.es
dc.description.filFil: Oliveira, Pedro F. Universidade do Porto. Instituto de Investigação e Inovação em Saúde; Portugal.es
dc.description.filFil: Calamita, Giuseppe. University of Bari “Aldo Moro”. Department of Biosciences, Biotechnologies and Biopharmaceutics; Italy.es
dc.description.sponsorshipRegione Puglia (Rete di Laboratori Pubblici di Ricerca WAFITECH-cod. 09)es
dc.description.sponsorshipConsejo Nacional de Investigaciones Científicas y Técnicas (CONICET): PIP 0244es
dc.description.sponsorshipAgencia Nacional de Promoción Científica y Tecnológica (ANPCyT): PICT 1217es
dc.description.sponsorshipFundação para a Ciência e a Tecnologia - Fundo Europeu de Desenvolvimento Regional—FEDER via Programa Operacional Factores de Competitividade—COMPETE/QREN: PTDC/BBB-BQB/1368/2014 and PEst-OE/SAU/UI0215/2014es
dc.description.sponsorshipFundação para a Ciência e a Tecnologia: SFRH/BD/103105/2014, SFRH/BPD/80451/2011 and SFRH/BPD/108837/2015es
dc.formatapplication/pdf
dc.format.extent1-20es
dc.identifier.issn1422-0067es
dc.identifier.urihttp://hdl.handle.net/2133/19958
dc.language.isoenges
dc.publisherMDPIes
dc.relation.publisherversionhttps://doi.org/10.3390/ijms17071096es
dc.relation.publisherversionhttps://www.mdpi.com/1422-0067/17/7/1096es
dc.rightsopenAccesses
dc.rights.holderUniversidad Nacional de Rosarioes
dc.rights.holderBernardino, Raquel L.es
dc.rights.holderMarinelli, Raúl A.es
dc.rights.holderMaggio, Annaes
dc.rights.holderGena, Patriziaes
dc.rights.holderCataldo, Ilariaes
dc.rights.holderAlves, Marco G.es
dc.rights.holderSvelto, Maríaes
dc.rights.holderOliveira, Pedro F.es
dc.rights.holderCalamita, Giuseppees
dc.rights.textAttribution 4.0 International (CC BY 4.0)es
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/*
dc.subjectMitochondriaes
dc.subjectReactive Oxygen Specieses
dc.subjectMetabolic Homeostasises
dc.subjectNon-alcoholic Fatty Liver Diseasees
dc.subjectBile Formationes
dc.subjectSpermatogenesises
dc.subjectMale Fertilityes
dc.titleHepatocyte and sertoli cell aquaporins, recent advances and research trendses
dc.typearticle
dc.typeartículo
dc.typepublishedVersion
dc.type.collectionarticulo
dc.type.versionpublishedVersiones

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