Insight into the factors controlling the equilibrium of allylic azides
| dc.citation.title | RSC Advances | es |
| dc.citation.volume | 10 | |
| dc.creator | Vallejos, Margarita M. | |
| dc.creator | Labadie, Guillermo Roberto | |
| dc.date.accessioned | 2020-05-28T12:21:05Z | |
| dc.date.available | 2020-05-28T12:21:05Z | |
| dc.date.issued | 2020-01-27 | |
| dc.description | Several allylic azides with different double bond substitutions were studied to understand the factors, governing their equilibrium using density functional theory along with the quantum theory of atoms in molecules, non-covalent interactions and natural bond orbital approaches. The results showed that the hydroxyl group or heteroatoms in allylic azides interact with the molecule through an electrostatic weak interaction in each pair of regioisomers. The equilibrium shifts of substituted allylic azides, compared to non-substituted allylic azides, were not attributed to the presence of specific interactions, such as hydrogen bonds. The observed equilibrium shifts stemmed mainly from the strengthening and weakening of negative hyperconjugative interactions, which were affected by the weak interaction involving the proximal substituent in each regioisomer. A good linear correlation was obtained between the hyperconjugative energies of πC[double bond, length as m-dash]C→σ*Zb interactions and the calculated percentages of the secondary azide and tertiary azide in the equilibrium mixture. Also, the effect of the aromatic ring substituent was analysed using such approaches. This study not only provides insights into the factors controlling the stabilities of the substituted allylic azides, but also settles the basis to predict the regioisomer predominance in the equilibrium mixture. | es |
| dc.description.fil | Fil: Vallejos, Margarita M. Universidad Nacional del Nordeste. Facultad de Ciencias Exactas, Naturales y Agrimensura. Instituto de Química Básica y Aplicada del Nordeste Argentino. Laboratorio de Química Orgánica (IQUIBA-NEA CONICET); Argentina. | es |
| dc.description.fil | Fil: Labadie, Guillermo Roberto. Universidad Nacional del Rosario. Facultad de Ciencias Bioquímicas y Farmaceúticas. Instituto de Química Rosario (IQUIR-CONICET); Argentina. | es |
| dc.description.sponsorship | Universidad Nacional del Nordeste(UNNE): SECY-UNNE PI No. 17F014 | es |
| dc.description.sponsorship | Agencia Nacional de Promoción Científica y Tecnológica (ANPCyT, Argentina): PICT 2014-3693 and PICT 2015- 2635 | es |
| dc.description.sponsorship | Universidad Nacional de Rosario (UNR): BIO 503 | es |
| dc.format | application/pdf | |
| dc.format.extent | 4404-4413 | es |
| dc.identifier.issn | 2046-2069 | es |
| dc.identifier.uri | http://hdl.handle.net/2133/18277 | |
| dc.language.iso | eng | es |
| dc.publisher | Royal Society of Chemistry | es |
| dc.relation.publisherversion | https://doi.org/10.1039/C9RA10093H | es |
| dc.relation.publisherversion | https://pubs.rsc.org/en/content/articlelanding/2020/ra/c9ra10093h#!divAbstract | es |
| dc.rights | openAccess | es |
| dc.rights.holder | Vallejos, Margarita M. | es |
| dc.rights.holder | Labadie, Guillermo Roberto | es |
| dc.rights.holder | Royal Society of Chemistry | es |
| dc.rights.holder | Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas | es |
| dc.rights.holder | Universidad Nacional del Nordeste | es |
| dc.rights.text | Attribution 3.0 Unported (CC BY 3.0) | es |
| dc.rights.uri | https://creativecommons.org/licenses/by/3.0/ | * |
| dc.subject | Allylic azides | es |
| dc.subject | Equilibrium | es |
| dc.subject | Regioisomer predominance | es |
| dc.title | Insight into the factors controlling the equilibrium of allylic azides | es |
| dc.type | article | |
| dc.type | artículo | |
| dc.type | publishedVersion | |
| dc.type.collection | articulo | |
| dc.type.version | publishedVersion | es |