NF-κB inhibitors, unique γ-pyranolγ-lactams with sulfde and sulfoxide moieties from Hawaiian plant Lycopodiella cernua derived fungus Paraphaeosphaeria neglecta FT462

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dc.citation.titleScientific Reportses
dc.citation.volume7es
dc.creatorLi, Chun-shun
dc.creatorSarotti, Ariel Marcelo
dc.creatorHuang, Peng
dc.creatorDang, Uyen T.
dc.creatorHurdle, Julian G.
dc.creatorKondratyuk, Tamara P.
dc.creatorPezzuto, John M.
dc.creatorTurkson, James
dc.creatorCao, Shugeng
dc.date.accessioned2021-02-19T16:26:29Z
dc.date.available2021-02-19T16:26:29Z
dc.date.issued2017-09-05
dc.descriptionLC-UV/MS-based metabolomic analysis of the Hawaiian endophytic fungus Paraphaeosphaeria neglecta FT462 led to the identifcation of four unique mercaptolactated γ-pyranol–γ-lactams, paraphaeosphaerides E–H (1–4) together with one γ-lactone (5) and the methyl ester of compound 2 (11). The structures of the new compounds (1–5 and 11) were elucidated through the analysis of HRMS and NMR spectroscopic data. The absolute confguration was determined by chemical reactions with sodium borohydride, hydrogen peroxide, α-methoxy-α-(trifuoromethyl)phenylacetyl chlorides (Mosher reagents), and DP4+NMR calculations. All the compounds were tested against STAT3, A2780 and A2780cisR cancer cell lines, E. coli JW2496, and NF-κB. Compounds 1 and 3 strongly inhibited NF-κB with IC50 values of 7.1 and 1.5μM, respectively.es
dc.description.filFil: Li, Chun-shun. University of Hawai'i at Hilo. Inouye College of Pharmacy. Department of Pharmaceutical Sciences; United States.es
dc.description.filFil: Li, Chun-shun. University of Hawaii Cancer Center. Cancer Biology Program; United States.es
dc.description.filFil: Sarotti, Ariel Marcelo. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Química Rosario (IQUIR -CONICET); Argentina.es
dc.description.filFil: Huang, Peng. University of Hawai'i at Hilo. Inouye College of Pharmacy. Department of Pharmaceutical Sciences; United States.es
dc.description.filFil: Huang, Peng. Anhui University of Chinese Medicine. College of Pharmacy; China.es
dc.description.filFil: Dang, Uyen T. Texas A&M University. Institute of Biosciences and Technology. Center for Infectious and Inflammatory Diseases; United States.es
dc.description.filFil: Dang, Uyen T. Texas A&M University. Texas A&M Health Science Center; United States.es
dc.description.filFil: Hurdle, Julian G. Texas A&M University. Institute of Biosciences and Technology. Center for Infectious and Inflammatory Diseases; United States.es
dc.description.filFil: Hurdle, Julian G. Texas A&M University. Texas A&M Health Science Center; United States.es
dc.description.filFil: Kondratyuk, Tamara P. University of Hawai'i at Hilo. Inouye College of Pharmacy. Department of Pharmaceutical Sciences; United States.es
dc.description.filFil: Pezzuto, John M. University of Hawai'i at Hilo. Inouye College of Pharmacy. Department of Pharmaceutical Sciences; United States.es
dc.description.filFil: Pezzuto, John M. Long Island University. Arnold & Marie Schwartz College of Pharmacy and Health Sciences; United States.es
dc.description.filFil: Turkson, James. University of Hawaii Cancer Center. Cancer Biology Program; United States.es
dc.description.filFil: Cao, Shugeng. University of Hawai'i at Hilo. Inouye College of Pharmacy. Department of Pharmaceutical Sciences; United States.es
dc.description.filFil: Cao, Shugeng. University of Hawaii Cancer Center. Cancer Biology Program; United States.es
dc.description.sponsorshipUniversity of Hawaii Cancer Centeres
dc.description.sponsorshipVictoria S. and Bradley L. Geist Foundation: 15ADVC-74420 y 17CON-86295es
dc.description.sponsorshipNational Institutes of Health (NIH)/National Cancer Institute (NCI): Grant CA161931es
dc.description.sponsorshipNational Institutes of Health (NIH)/National Center for Complementary and Integrative Health (NCCIH): Grant 5R01AT006732es
dc.formatapplication/pdf
dc.format.extent1-10es
dc.identifier.issn2045-2322es
dc.identifier.urihttp://hdl.handle.net/2133/19657
dc.language.isoenges
dc.publisherNaturees
dc.relation.publisherversionhttps://doi.org/10.1038/s41598-017-10537-1es
dc.relation.publisherversionhttps://www.nature.com/articles/s41598-017-10537-1es
dc.rightsopenAccesses
dc.rights.holderUniversidad Nacional de Rosarioes
dc.rights.holderLi, Chun-shunes
dc.rights.holderSarotti, Ariel Marceloes
dc.rights.holderHuang, Penges
dc.rights.holderDang, Uyen T.es
dc.rights.holderHurdle, Julian G.es
dc.rights.holderKondratyuk, Tamara P.es
dc.rights.holderPezzuto, John M.es
dc.rights.holderTurkson, Jameses
dc.rights.holderCao, Shugenges
dc.rights.textAttribution 4.0 International (CC BY 4.0)es
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/*
dc.subjectLycopodiella cernuaes
dc.subjectParaphaeosphaeria neglectaes
dc.subjectBiologically Active Secondary Metaboliteses
dc.subjectNF-κB Inhibitorses
dc.titleNF-κB inhibitors, unique γ-pyranolγ-lactams with sulfde and sulfoxide moieties from Hawaiian plant Lycopodiella cernua derived fungus Paraphaeosphaeria neglecta FT462es
dc.typearticle
dc.typeartículo
dc.typepublishedVersion
dc.type.collectionarticulo
dc.type.versionpublishedVersiones

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