Metal-mediated synthesis of pyrrolines

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dc.citation.titleRSC Advances
dc.citation.volume9
dc.contributor.orcidhttps://orcid.org/0000-0002-0185-5751
dc.creatorMedran, Noelia Soledad
dc.creatorLa Venia, Agustina
dc.creatorTestero, Sebastián A.
dc.date.accessioned2024-10-31T18:17:50Z
dc.date.available2024-10-31T18:17:50Z
dc.date.issued2019-02-27
dc.description.abstractThe five-membered, nitrogen-containing pyrroline ring is a privileged structure. This ring is present in many bioactive compounds from natural sources. Pyrrolines—the dihydro derivatives of pyrroles—have three structural isomer classes, depending on the location of the double bond: 1-pyrrolines (3,4-dihydro-2H-pyrroles), 2-pyrrolines (2,3-dihydro-1H-pyrroles) and 3-pyrrolines (2,5-dihydro-1H-pyrroles). This review aims to describe the latest advances for the synthesis of pyrrolines by transition metal-catalyzed cyclizations. Only reactions in which the pyrroline ring is formed by metal promotion are described. Transformations of the pyrroline ring in other heterocycles, and the structural manipulations of the pyrroline itself are not discussed. The review is organized into three parts, each covering the metal-mediated synthesis of the three pyrroline isomers. Each part is subdivided according to the metal involved, and concludes with a brief description of notable biological activities within the class.
dc.description.filFil: Medran, Noelia Soledad. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Química Rosario (IQUIR-CONICET); Argentina.
dc.description.filFil: La Venia, Agustina. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Química Rosario (IQUIR-CONICET); Argentina.
dc.description.filFil: Testero, Sebastián A. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Química Rosario (IQUIR-CONICET); Argentina.
dc.description.sponsorshipConsejo Nacional de Investigaciones Científicas y Técnicas
dc.description.sponsorshipAgencia Nacional de Promoción Científica y Tecnológica: PICT-2015-2449, PICT-2016-1069
dc.format.extent6804–6844
dc.identifier.citationMedran, Noelia Soledad; la Venia, Agustina; Testero, Sebastian Andres; Metal-mediated synthesis of pyrrolines; Royal Society of Chemistry; RSC Advances; 9; 12; 2-2019; 6804-6844
dc.identifier.issn2046-2069
dc.identifier.urihttps://hdl.handle.net/2133/28017
dc.language.isoen
dc.publisherRoyal Society of Chemistry
dc.relation.publisherversionhttps://doi.org/10.1039/C8RA10247C
dc.relation.publisherversionhttps://pubs.rsc.org/en/content/articlelanding/2019/ra/c8ra10247c#!divCitation
dc.rightsopenAccess
dc.rights.holderThe Royal Society of Chemistry
dc.rights.holderUniversidad Nacional de Rosario
dc.rights.textAttribution-NonCommercial 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/
dc.subjectPyrroles
dc.subjectCyclization
dc.subjectCatalysis
dc.subjectHeterocyclic Compounds
dc.titleMetal-mediated synthesis of pyrrolines
dc.typearticulo
dc.type.collectionarticulo
dc.type.versionpublishedVersion

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