Examinando por Autor "Del Olmo, Esther"

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    Synthesis, Bioevaluation and Structural Study of Substituted Phthalazin-1(2H)-ones Acting as Antifungal Agents
    (MDPI Open Access Publishing, 2013-03) Derita, Marcos Gabriel; Del Olmo, Esther; Barboza, Bianca; García Cadenas, Ana E.; López Pérez, José L.; Andújar, Sebastián; Enriz, Ricardo Daniel; Zacchino, Susana; San Feliciano, Arturo
    Twenty-five polysubstituted phthalazinone derivatives were synthesized and tested for their antifungal activity against a panel of pathogenic and clinically important yeasts and filamentous fungi. Among them, the compound 4-(4-chlorobenzyl)-2- methylphthalazin-1(2H)-one (5) exhibited a remarkable antifungal activity against standardised strains of dermatophytes and Cryptococcus neoformans, as well as against some clinical isolates. A physicochemical study performed on compound 5 revealed its conformational and electronic characteristics, providing us with useful data for the future design of novel related antifungal analogues.