Derita, Marcos GabrielDel Olmo, EstherBarboza, BiancaGarcía Cadenas, Ana E.López Pérez, José L.Andújar, SebastiánEnriz, Ricardo DanielZacchino, SusanaSan Feliciano, Arturo2013-05-292013-05-292013-03Derita M, del Olmo E, Barboza B, García-Cadenas AE, López-Pérez JL, Andújar S, Enriz D, Zacchino S, San Feliciano A. Synthesis, Bioevaluation and Structural Study of Substituted Phthalazin-1(2H)-ones Acting as Antifungal Agents. Molecules. 2013; 18(3):3479-3501.1420-3049http://hdl.handle.net/2133/2584Twenty-five polysubstituted phthalazinone derivatives were synthesized and tested for their antifungal activity against a panel of pathogenic and clinically important yeasts and filamentous fungi. Among them, the compound 4-(4-chlorobenzyl)-2- methylphthalazin-1(2H)-one (5) exhibited a remarkable antifungal activity against standardised strains of dermatophytes and Cryptococcus neoformans, as well as against some clinical isolates. A physicochemical study performed on compound 5 revealed its conformational and electronic characteristics, providing us with useful data for the future design of novel related antifungal analogues.enopenAccessCreative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/)benzylphthalazinonesantifungalCryptococcus neoformansdermatophytes structure–activity relationshipsconformational studyarticle© 2013 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).