2020-05-282020-05-282019-110039-128Xhttp://hdl.handle.net/2133/18280A simple and efficient method to synthesize the immunogenic glycolipid BbGL1 is introduced. Two simple steps were required to obtain the desired product in good yield. First, a highly efficient glycosylation of cholesterol using galactosyl trichloroacetimidate as a donor was performed to produce cholesteryl-β-d-galactoside. Finally, an efficient palmitoylation on the C6–OH of the galactose of the synthesized saponin using sym-collidine and acyl chloride under microwave heating that produced BbGL1 in good yield. The procedure is a convenient and cheaper alternative to the reported procedures allowing a rapid preparation of multiple analogs and conjugates.application/pdf41-45engopenAccessAcyl steryl glycosidesBbGL1Lyme diseaseMicrowave heatingSelective acylationarticleJäger, Sebastián N.Porta, Exequiel O. J.Labadie, Guillermo RobertoElsevierUniversidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y FarmacéuticasAtribución-NoComercial-SinDerivadas 4.0 Internacional (CC BY-NC-ND 4.0)