2020-12-222020-12-222017-07-121420-3049http://hdl.handle.net/2133/19532A new N-methoxypyridone analog (1), together with four known compounds, was isolated from the co-culture of Hawaiian endophytic fungi Camporesia sambuci FT1061 and Epicoccum sorghinum FT1062. The structure of the new compound was elucidated as 11S-hydroxy-1-methoxyfusaricide (1) by extensive spectroscopic analysis and comparison with the literature. The absolute configuration of 1 was determined by comparison with the experimental and calculated ECD spectra. The absolute configuration of compound 3 was investigated and renamed as (+)-epipyridone by comparison of the optical rotation and CD spectrum with those of 1. The other known compounds were identified as epicoccarine B (2), D8646-2-6 (4), and iso-D8646-2-6 (5). Compounds 4 and 5 showed modest inhibitory activity towards pathogenic fungi. Epicoccarine B (2) inhibited A2780 and TK-10 with an IC50 value of 22 µM.Para citar este articulo: Li, C.; Sarotti, A.M.; Yang, B.; Turkson, J.; Cao, S. A New N-methoxypyridone from the Co-Cultivation of Hawaiian Endophytic Fungi Camporesia sambuci FT1061 and Epicoccum sorghinum FT1062. Molecules 2017, 22, 1166.application/pdf1-8engopenAccessEndophytic FungiCoculture TechniquesPyridonesTetramic AcidHawaiiarticleUniversidad Nacional de RosarioLi, ChunshunSarotti, Ariel MarceloYang, BaojunTurkson, JamesCao, ShugengAttribution 4.0 International (CC BY 4.0)