2020-12-172020-12-172018-05-161420-3049http://hdl.handle.net/2133/19505The application of the reagent-based diversification strategy for generation of libraries of biologically promising β-lactam derivatives is described. Key features are the versatility of the linker used and the cross-metathesis functionalization at the cleavage step. From an immobilized primary library, diversity was expanded by applying different cleavage conditions, leading to a series of cholesterol absorption inhibitor analogues together with interesting hybrid compounds through incorporation of a chalcone moiety.Para citar este articulo: Méndez, L.; Poeylaut-Palena, A.A.; Mata, E.G. Molecular Diversity by Olefin Cross-Metathesis on Solid Support. Generation of Libraries of Biologically Promising β-Lactam Derivatives. Molecules 2018, 23, 1193.application/pdf1-15engopenAccessDiversity-oriented SynthesisSolid-Phase Organic Synthesisbeta-Lactam DerivativesAlkenesMetathesisCholesterol Absorption InhibitorsarticleUniversidad Nacional de RosarioMéndez, LucianaPoeylaut-Palena, Andrés A.Mata, Ernesto GabinoAttribution 4.0 International (CC BY 4.0)