2024-06-142024-06-142020-08-262379-5042https://hdl.handle.net/2133/27319Disruption of the histone-like nucleoid structuring protein (H-NS) was shown to affect the ability of Gram-negative bacteria to regulate genes associated with virulence, persistence, stress response, quorum sensing, biosynthesis pathways, and cell adhesion. Here, we used the expression of metallo--lactamases (MBLs), known to elicit envelope stress by the accumulation of toxic precursors in the periplasm, to interrogate the role of H-NS in Acinetobacter baumannii, together with other stressors. Using a multidrug-resistant A. baumannii strain, we observed that H-NS plays a role in alleviating the stress triggered by MBL toxic precursors and counteracts the effect of DNA-damaging agents, supporting its role in stress response.1-6enopenAccessAcinetobacter baumanniiH-NSStressCarbapenemasesAcinetobacterCarbapenemsarticuloHuang, FannyFitchett, NoelleRazo Gutiérrez, ChelseaLe, CasinMartínez, JasmineRa, GraceLópez, CarolinaGonzález, Lisandro JavierSieira, RodrigoVila, Alejandro J.Bonomo, Robert A.Ramírez, María SoledadUniversidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y FarmacéuticasATTRIBUTION 4.0 INTERNATIONAL CC BY 4.0