2024-05-242024-05-2420202046-2069https://hdl.handle.net/2133/27084The isolation, biological activity and synthesis of natural furo[3,2-c]coumarins are presented, covering mainly the developments in the last 35 years. The most relevant approaches toward the synthesis of 2- substituted, 3-substituted and 2,3-disubstituted heterocycles are also discussed, with emphasis on the efficiency of the processes and their mechanisms.33344-33377enopenAccessHeterocyclesFuro[3,2-c]coumarinsOrganic synthesisFuro[3,2-c]coumarins carrying carbon substituents at C-2 and/or C-3. Isolation, biological activity, synthesis and reaction mechanismsarticuloThe Royal Society of ChemistryAttribution-NonCommercial 4.0 International