EURECA (Eukaryote DNA Repair Capacity) una plataforma web con una base de datos sobre sistemas de reparación indirecta del ADN en eucariotas y con herramientas bioinformáticas
Fecha
2021
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Universidad Nacional de Rosario. Facultad de Ciencias Agrarias
Resumen
Descripción
Los organismos vivos nos encontramos continuamente expuestos a
factores bióticos y/o abióticos que pueden producir daño en el ADN; sin
embargo, existen mecanismos para repararlo. Dentro de ellos, se encuentran
los mecanismos de reparación indirecta que incluyen a los sistemas BER
(reparación por escisión de bases), NER (reparación por escisión de
nucleótidos) y MMR (reparación de apareamiento incorrecto). Existe una gran
cantidad de publicaciones e información disponible sobre estos mecanismos
para diversas especies, especialmente para humanos y en menor medida para
plantas. Sin embargo, los datos se encuentran dispersos y es necesario
organizar y centralizarlos en una plataforma disponible para la comunidad
científica. Con este objetivo se planteó crear a EURECA (Eukaryote DNA
Repair Capacity), una plataforma web gratuita que incluye una base de datos
con herramientas bioinformáticas básicas, pero útiles para el estudio de los
sistemas de reparación indirectos del ADN de eucariotas, lo que facilitará el
acceso a la información existente y por consiguiente, su estudio.
Living organisms are continuously exposed to either by biotic or abiotic factors that can cause DNA damage; however, there are mechanisms to repair it. These include the indirect repair mechanisms including the BER (Base Excision Repair), NER (Nucleotide Excision Repair) and MMR (Mismatch Repair) systems. There is a large amount of literature and information available regarding these mechanisms in various species, particularly in humans and, to a lesser extent, in plants. However, the data is scattered and needs to be organized and centralized in a platform available to the scientific community. For this purpose EURECA (Eukaryote DNA Repair Capacity) was created; it is a free web platform that includes a database with basic useful bioinformatics tools to study the indirect DNA repair systems of eukaryotes, which will facilitate access to existing information and its study.
Living organisms are continuously exposed to either by biotic or abiotic factors that can cause DNA damage; however, there are mechanisms to repair it. These include the indirect repair mechanisms including the BER (Base Excision Repair), NER (Nucleotide Excision Repair) and MMR (Mismatch Repair) systems. There is a large amount of literature and information available regarding these mechanisms in various species, particularly in humans and, to a lesser extent, in plants. However, the data is scattered and needs to be organized and centralized in a platform available to the scientific community. For this purpose EURECA (Eukaryote DNA Repair Capacity) was created; it is a free web platform that includes a database with basic useful bioinformatics tools to study the indirect DNA repair systems of eukaryotes, which will facilitate access to existing information and its study.
Palabras clave
Eucariotas, Reparación de ADN, Bases de datos, EURECA, Programas de ordenador