Radical oxygen species and bile secretion

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dc.creator Basiglio, Cecilia Lorena
dc.creator Toledo, Flavia D.
dc.creator Sánchez Pozzi, Enrique J.
dc.creator Roma, Marcelo G.
dc.date.accessioned 2019-02-22T20:44:09Z
dc.date.available 2019-02-22T20:44:09Z
dc.date.issued 2014-05
dc.identifier.isbn 978-3-642-30018-9 es
dc.identifier.uri http://hdl.handle.net/2133/14092
dc.description.abstract Oxidative stress is a common feature in most hepatopathies. Accumulating evidences indicate that reactive oxygen species (ROS) induce a number of functional changes either deleterious or adaptive in the capability of the hepatocytes to produce bile and to secrete exogenous and endogenous compounds. This review is aimed to describe the mechanisms involved in these changes. For this purpose, we will summarize: 1. The current evidence that acutely induced oxidative stress is cholestatic, by describing the mechanisms underlying the hepatocyte secretory failure, including the disorganization of the actin cytoskeleton and its most noticeable consequences, that is, the impairment of tight-junctional structures and the endocytic internalization of canalicular transporters relevant to bile formation. 2. The role for oxidative-stress-activated signalling pathways in the pathomechanisms described above, particularly those involving Ca2+ elevation and its consequent activation via Ca2+ of “classical” and “novel” PKC isoforms. 3. The mechanisms involved in the adaptive response against oxidative stress mediated by ROS-responsive transcription factors, such as upregulation of GSH synthesis pathway, antioxidant enzymes, and hepatocellular efflux pumps. 4. The consequences on hepatocellular secretory function when this adaptive response can be surpassed by the sustained/high production of ROS. This deleterious effects include transcriptional and posttranscriptional changes in the expression of transporters relevant to bile formation, as has been shown to occur, for example, after long-term administration of aluminum to rats, in the Long-Evans Cinnamon rat (a model of chronic hepatic copper accumulation mimicking Wilson’s disease), and in ischemia-reperfusion injury. es
dc.format application/pdf
dc.format.extent 1787 - 1808 es
dc.language.iso eng es
dc.publisher Springer es
dc.rights openAccess es
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es *
dc.subject Canalicular transporters es
dc.subject Oxidative Stress es
dc.subject Bile Secretion es
dc.subject Signalling es
dc.subject Cholestasis es
dc.subject Protein kinases es
dc.subject Tight junctions es
dc.title Radical oxygen species and bile secretion es
dc.type bookPart
dc.type parte de libro
dc.type acceptedVersion
dc.rights.holder Basiglio, Cecilia Lorena es
dc.rights.holder Toledo, Flavia D. es
dc.rights.holder Sánchez Pozzi, Enrique J. es
dc.rights.holder Roma, Marcelo G. es
dc.rights.holder Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas es
dc.rights.holder Springer es
dc.relation.publisherversion http://dx.doi.org/10.1007/978-3-642-30018-9_140 es
dc.relation.publisherversion https://link.springer.com/referenceworkentry/10.1007%2F978-3-642-30018-9_140 es
dc.rights.text Atribución-NoComercial-SinDerivadas 4.0 Internacional (CC BY-NC-ND 4.0) es
dc.citation.title Systems biology of free radicals and antioxidants es
dc.description.fil Fil: Basiglio, Cecilia Lorena. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Fisiología Experimental (IFISE‑CONICET); Argentina. es
dc.description.fil Fil: Toledo, Flavia D. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Fisiología Experimental (IFISE‑CONICET); Argentina. es
dc.description.fil Fil: Sánchez Pozzi, Enrique J. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Fisiología Experimental (IFISE‑CONICET); Argentina. es
dc.description.fil Fil: Roma, Marcelo G. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Fisiología Experimental (IFISE‑CONICET); Argentina. es
dc.type.collection capitulo_libro
dc.type.version acceptedVersion es


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