FCM - Instituto de Inmunología
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Examinando FCM - Instituto de Inmunología por Autor "Bottasso, Oscar"
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Ítem Acceso Abierto A multicenter prospective study of 515 febrile neutropenia episodes in Argentina during a 5-year period(PLOS, 2019-10-31) Parodi, Roberto Leandro; Lagrutta, Mariana; Tortolo, Mauro; Navall, Estefanía; Rodríguez, María S.; Sasia, Gervasio Flavio; de Candia, Lucas F.; Gruvman, Matias A.; Bottasso, Oscar; Greca, Alcides AlejandroÍtem Acceso Abierto A Multifaceted Analysis of Immune-Endocrine-Metabolic Alterations in Patients with Pulmonary Tuberculosis(PLOS, 2011-10-13) Santucci, Natalia; D'Attilio, Luciano; Kovalevski, Leandro; Bozza, Verónica; Besedovsky, Hugo; del Rey, Adriana; Bay, María Luisa; Bottasso, OscarOur study investigated the circulating levels of factors involved in immune-inflammatory-endocrine-metabolic responses in patients with tuberculosis with the aim of uncovering a relation between certain immune and hormonal patterns, their clinical status and in vitro immune response. The concentration of leptin, adiponectin, IL-6, IL-1β, ghrelin, C-reactive protein (CRP), cortisol and dehydroepiandrosterone (DHEA), and the in vitro immune response (lymphoproliferation and IFN-γ production) was evaluated in 53 patients with active untreated tuberculosis, 27 household contacts and 25 healthy controls, without significant age- or sex-related differences. Patients had a lower body mass index (BMI), reduced levels of leptin and DHEA, and increased concentrations of CRP, IL-6, cortisol, IL-1β and nearly significant adiponectin values than household contacts and controls. Within tuberculosis patients the BMI and leptin levels were positively correlated and decreased with increasing disease severity, whereas higher concentrations of IL-6, CRP, IL-1β, cortisol, and ghrelin were seen in cases with moderate to severe tuberculosis. Household contacts had lower DHEA and higher IL-6 levels than controls. Group classification by means of discriminant analysis and the k-nearest neighbor method showed that tuberculosis patients were clearly different from the other groups, having higher levels of CRP and lower DHEA concentration and BMI. Furthermore, plasma leptin levels were positively associated with the basal in vitro IFN-γ production and the ConA-driven proliferation of cells from tuberculosis patients. Present alterations in the communication between the neuro-endocrine and immune systems in tuberculosis may contribute to disease worsening.Ítem Acceso Abierto Assessment of Cross-reactive Host-pathogen Antibodies in Patients With Different Stages of Chronic Chagas Disease(Sociedad Española de Cardiología, 2013-10) Vicco, Miguel H.; Ferini, Franco; Rodeles, Luz; Cardona, Paula; Bontempi, Iván; Lioi, Susana; Beloscar, Juan; Nara, Takeshi; Marcipar, Iván; Bottasso, OscarIntroduction and objectives Trypanosoma cruzi infection has been shown to induce humoral autoimmune responses against host antigens tissues. Particularly, antibodies cross-reacting with myocardial antigens may play a role in the development of the severe forms of chronic Chagas disease. The aim of this study was to determine the association between clinical stage of the disease and the presence of autoantibodies in patients with chronic Chagasic disease. Methods We performed a cross-sectional study in T. cruzi-seropositive patients divided into 3 groups according to the classic classification of chronic Chagas heart of Storino et al. All participants underwent complete clinical examination and their sera were used to measure autoantibody levels. Results All patients had detectable levels of anti-p2β and anti-B13 autoantibodies but none had anti-Na-K-ATPase antibodies. No association was observed between electrocardiographic conduction disturbances and autoantibody levels. Patients with chronic Chagas disease stage III had the highest levels of anti-B13 antibodies and a high risk of mortality score, showing a clear association between disease stage and this score. Conclusions Anti-B13 antibodies were significantly higher in chronic Chagas disease stage III patients, suggesting that these antibodies may be involved in disease progression and that they might be a useful marker of poor prognosis in terms of heart compromise. Our results also reveal an important correlation between the level of anti-B13 autoantibodies and symptomatic heart failure and/or dilated cardiomyopathy.Ítem Acceso Abierto Características clínico-epidemiológicas de la estrongiloidiasis en pacientes portadores de co-morbilidades(Sociedad Chilena de Infectología, 2017-02) Regueira Fernandes, Amanda; Romero, Sebastián; Alcântara de Souza Melo, Paula Fernanda; Ramos Araújo, Paulo Sérgio; Bottasso, Oscar; Rocha, Abraham; Brandão, EduardoÍtem Acceso Abierto Death of adrenocortical cells during murine acute T. cruzi infection is not associated with TNF-R1 signaling but mostly with the type II pathway of Fas-mediated apoptosis(Academic Press Inc Elsevier Science, 2017-10) Pérez, Ana Rosa; Lambertucci, Flavia; González, Florencia Belén; Roggero, Eduardo Angel; Bottasso, Oscar; de Meis, Juliana; Ronco, Maria Teresa; Villar, Silvina RaquelÍtem Acceso Abierto Los dolores silenciados de María R.(Ediciones Universidad de Salamanca, 2012-03) Bottasso, OscarÍtem Acceso Abierto Dynamics of Adrenal Steroids Are Related to Variations in Th1 and Treg Populations during Mycobacterium tuberculosis Infection in HIV Positive Persons(PLOS (Public Library of Science), 2012-03-04) Quiroga, Maria Florencia; Angerami, Matias Tomas; Santucci, Natalia; Ameri, Diego; Francos, Jose Luis; Wallach, Jorge; Sued, Omar; Cahn, Pedro; Salomón, Horacio; Bottasso, OscarTuberculosis (TB) remains the most frequent cause of illness and death from an infectious agent, and its interaction with HIV has devastating effects. We determined plasma levels of dehydroepiandrosterone (DHEA), its circulating form DHEA-suphate (DHEA-s) and cortisol in different stages of M. tuberculosis infection, and explored their role on the Th1 and Treg populations during different scenarios of HIV-TB coinfection, including the immune reconstitution inflammatory syndrome (IRIS), a condition related to antiretroviral treatment. DHEA levels were diminished in HIV-TB and HIV-TB IRIS patients compared to healthy donors (HD), HIV+ individuals and HIV+ individuals with latent TB (HIV-LTB), whereas dehydroepiandrosterone sulfate (DHEA-s) levels were markedly diminished in HIV-TB IRIS individuals. HIV-TB and IRIS patients presented a cortisol/DHEA ratio significantly higher than HIV+, HIV-LTB and HD individuals. A positive correlation was observed between DHEA-s and CD4 count among HIV-TB individuals. Conversely, cortisol plasma level inversely correlated with CD4 count within HIV-TB individuals. M. tuberculosis-specific Th1 lymphocyte count was increased after culturing PBMC from HIV-TB individuals in presence of DHEA. We observed an inverse correlation between DHEA-s plasma level and Treg frequency in co-infected individuals, and CD4+FoxP3+ Treg frequency was increased in HIV-TB and IRIS patients compared to other groups. Strikingly, we observed a prominent CD4+CD25-FoxP3+ population across HIV-TB and HIV-TB IRIS patients, which frequency correlated with DHEA plasma level. Finally, DHEA treatment negatively regulated FoxP3 expression without altering Treg frequency in co-infected patients. These data suggest an enhancing role for DHEA in the immune response against M. tuberculosis during HIV-TB coinfection and IRIS.Ítem Acceso Abierto Dysregulated Network of Immune, Endocrine and Metabolic Markers is Associated to More Severe Human Chronic Chagas Cardiomyopathy(S. Karger AG, 2018-09-25) González, Florencia Belén; Villar, Silvina Raquel; D'Attilio, Luciano; Leiva, Rodolfo; Marquez, Julia; Lioi, Susana; Beloscar, Juan; Bottasso, Oscar; Pérez, Ana RosaÍtem Acceso Abierto Early double-negative thymocyte export in Trypanosoma cruzi infection is restricted by sphingosine receptors and associated with human chagas disease.(PLOS (Public Library of Science), 2014-10-16) Lepletier, Ailin; de Almeida, Liliane; Santos, Leonardo; da Silva Sampaio, Luzia; Paredes, Bruno; González, Florencia Belén; Freire-de-Lima, Célio Geraldo; Beloscar, Juan; Bottasso, Oscar; Einicker-Lamas, Marcelo; Pérez, Ana Rosa; Savino, Wilson; Morrot, AlexandreÍtem Acceso Abierto Estrés e inmunidad, entre lo tradicional y más neoclásico, con una incursión en los efectos a largo plazo(Círculo Médico de Rosario, 2021-04-21) Bottasso, OscarÍtem Acceso Abierto Fantasías con el cello. Alguna que otra emoción(Círculo Médico de Rosario, 2016-04) Bottasso, OscarÍtem Acceso Abierto El hacedor de su propia semiología(2018-07) Bottasso, OscarÍtem Acceso Abierto Hacia una concepción más abarcadora de la inflamación(Círculo Médico de Rosario, 2018) Bottasso, OscarÍtem Acceso Abierto Hechos salientes en la inmunopatología de la infección por SARSCoV2(Facultad de Ciencias Médicas. Universidad Nacional de Rosario, 2020-04-29) Bottasso, Oscar; Facultad de Ciencias Médicas. Universidad Nacional de RosarioCharla sobre "Hechos salientes en la inmunopatología de la infección por SARSCoV2" organizada por la Facultad de Ciencias Médicas de la UNR en el Día Internacional de la Inmunología realizada el día 29/04/20 y disponible en YouTube https://youtu.be/GvUSxHHY1nAÍtem Acceso Abierto Malaria para la sífilis. Una historia donde la beneficiencia traspasó sus límites(Círculo Médico de Rosario, 2017-04) Bottasso, OscarÍtem Acceso Abierto Ítem Acceso Abierto El otro Claudio, o cuando la fisiología se puso los pantalones largos(2019-02-04) Bottasso, OscarÍtem Acceso Abierto La pandemia COVID-19. Sus rasgos más distintivos(Universidad Nacional de Rosario. Consejo de Investigaciones, 2020-08) Bottasso, OscarHacia fines de noviembre de 2019, comenzó a detectarse una serie de casos de neumonía sin diagnóstico etiológico preciso en Wuhan, China. Poco tiempo después, concretamente a principios de enero de 2020 fue posible determinar que su agente causal era un nuevo coronavirus, inicialmente denominado 2019-nCoV y luego coronavirus-2 del síndrome respiratorio agudo severo (SARS-CoV-2), aunque también se lo suele identificar como COVID-19. La enfermedad que afecta particularmente las vías respiratorias se generalizó rápidamente dado la transmisión entre personas, habiendo ocasionado brotes significativos a nivel planetario con un variado espectro de morbilidad y una tasa de mortalidad que en líneas generales oscila entre un 3 y 4%. El 11 de marzo de 2020, la OMS declaró la pandemia COVID-19; la cual ha puesto en jaque a los sistemas de salud y la economía global, atento a los desafíos que plantean las pautas de prevención, la atención clínica y las cuestiones socioeconómicas vinculadas a las medidas de aislamiento y la consabida cuarentena.Ítem Acceso Abierto El requiem, un romanzo y una plaga. Alessandro Manzoni, Giuseppe Verdi y las historias de antiguas epidemias(2020-04-20) Bottasso, OscarÍtem Acceso Abierto Short treatment with the tumour necrosis factor-α blocker infliximab diminishes chronic chagasic myocarditis in rats without evidence of Trypanosoma cruzi reactivation(British Society for Immunology, 2009-08) Pérez, Ana Rosa; Fontenella, Germán Héctor; Nocito, Ana Lía; Revelli, Silvia; Bottasso, Oscar