Annexin A2 and S100A10 in the mammalian oviduct

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dc.creator Teijeiro, Juan Manuel
dc.creator Roldán, María Lorena
dc.creator Marini, Patricia Estela
dc.date.accessioned 2017-11-22T19:17:36Z
dc.date.available 2017-11-22T19:17:36Z
dc.date.issued 2015-09
dc.identifier.issn 0302-766X es
dc.identifier.uri http://hdl.handle.net/2133/9344
dc.description In many mammals, upon entry into the female reproductive tract, a subpopulation of sperm is stored in the oviduct forming a functional reservoir. In the oviducts of pig and cow, Annexin A2 (AnxA2) has been linked to the binding of sperm. This protein may exist as a monomer or bound to S100A10 and both forms are associated with different biological functions. S100A10 has not yet been reported in the oviduct. The objective of this work is to analyze for the presence of S100A10 in the oviduct and to advance the study of AnxA2 and S100A10 in this organ. This work shows the presence of both proteins, AnxA2 and S100A10, in the oviduct of human, pig, cow, cat, dog and rabbit. At least in pig, AnxA2 is found devoid of S100A10 in the outer surface of the apical plasma membrane of oviductal epithelial cells, indicating that it binds to sperm as a monomer or in association with proteins different from S100A10. In the apical cytoplasm of pig oviductal epithelial cells, AnxA2 is associated with S100A10. In primary culture of porcine oviductal cells, the expression of ANXA2 is increased by progesterone, while the expression of S100A10 is increased by progesterone and estradiol. The widespread detection of both proteins in the oviduct of mammals indicates a probable conserved function in this organ. In summary, S100A10 and AnxA2 are widespread in the mammalian oviduct but AnxA2 binds sperm in vivo devoid of S100A10 and may be related to reservoir formation. es
dc.format application/pdf
dc.format.extent 567-77 es
dc.language.iso eng es
dc.publisher Springer-Verlag es
dc.rights openAccess es
dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/2.5/ar/ *
dc.subject Anexina es
dc.subject S100A10 es
dc.subject Trompas de Falopio es
dc.subject Reservorio de espermatozoides es
dc.subject Oviducto es
dc.title Annexin A2 and S100A10 in the mammalian oviduct es
dc.type article
dc.type artículo
dc.type publishedVersion
dc.rights.holder Springer-Verlag Berlin Heidelberg es
dc.relation.publisherversion https://link.springer.com/article/10.1007%2Fs00441-015-2266-9 es
dc.relation.publisherversion https://doi.org/10.1007/s00441-015-2266-9 es
dc.citation.title Cell and Tissue Research es
dc.citation.volume 363(2) es
dc.description.fil Fil: Teijeiro, Juan Manuel. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Laboratorio de Medicina Reproductiva (UNR-CONICET); Argentina es
dc.description.fil Fil: Roldán, María Lorena. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Biología Molecular y Celular de Rosario (UNR-CONICET); Argentina es
dc.description.fil Fil: Marini, Patricia Estela. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Laboratorio de Medicina Reproductiva (UNR-CONICET); Argentina es
dc.description.fil Fil: Marini, Patricia Estela. Universidad Nacional de Rosario. Consejo de Investigaciones; Argentina es
dc.description.fil Fil: Marini, Patricia Estela. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Biología Molecular y Celular de Rosario (UNR-CONICET); Argentina es
dc.type.collection articulo
dc.type.version publishedVersion es


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