FCM - Instituto de Genética Experimental

Repositorio RepHipUNR

FCM - Instituto de Genética Experimental

Envíos recientes

  • Binda, María Mercedes; Matar, Pablo; González, Alejandro D.; Rozados, Viviana R.; Gervasoni, Silvia I.; Scharovsky, O. Graciela; Bonfil, R. Daniel (Wiley, 2002-05-02)
    The phenomenon by which tumor-bearing hosts are capable of inhibiting secondary tumor implants or metastases, known as concomitant antitumoral resistance (CAR), is presumably due to antiangiogenesis at places distant from ...
  • Rico, María José; Matar, Pablo; Scharovsky, O. Graciela (Sociedad Latinoamericana de Microscopía Electrónica. Centro Regional de Investigaciones Científicas y Tecnológicas (Mendoza, Argentina), 2012-08)
    We have already shown that IL-10 plays an important role in immunosuppression and metastatic dissemination in the rat B-cell lymphoma L-TACB model. It was suggested that the up-regulation of IL-10 production and IL-10 ...
  • Rozados, Viviana R.; Hinrichsen, Lucila Isabel; Binda, María Mercedes; Gervasoni, Silvia I.; Matar, Pablo; Bonfil, Daniel R.; Scharovsky, O. Graciela (Spandidos (Grecia), 2008-05)
    Despite its effectiveness as an antineoplastic drug, doxorubicin (DOX) is usually associated with cardiotoxicity. Lovastatin (LOV), a hypolipidemic agent used in the clinic, has been demonstrated to have antitumoral and ...
  • Rozados, Viviana R.; Sánchez, Andrea M.; Gervasoni, Silvia I.; Berra, Héctor H.; Matar, Pablo; Scharovsky, O. Graciela (Oxford University Press, 2004-10)
    BACKGROUND: Our aim was to investigate the clinical efficacy and toxicity of metronomic administration of low-dose cyclophosphamide (Cy) in lymphoma and sarcoma rat tumour models. METHODS: Adult inbred rats were challenged ...
  • Scharovsky, O. Graciela (Círculo Médico de Rosario (Argentina), 2001-07)
    La terapia génica es una forma de medicina molecular que probablemente tendrá un gran impacto en la salud humana a lo largo del siglo XXI. Tiene como objetivo modificar o reparar una alteración genética adquirida, corregir ...
  • Rozados, Viviana R.; Mainetti, Leandro Ernesto; Rico, María José; Zacarías Fluck, Mariano; Matar, Pablo; Scharovsky, O. Graciela (Cognizant Communication Corporation, 2010-11-01)
    Metronomic chemotherapy (MCT) is a novel therapeutic strategy for cancer treatment endowed with an antiangiogenic effect. It refers to regular administration of low doses of cytotoxic drugs, with minimal or no drug-free ...
  • Malvicini, Mariana; Rizzo, Miguel; Alaniz, Laura; Piñero, Federico; García, Mariana; Atorrasagasti, Catalina; Aquino, Jorge B.; Rozados, Viviana R.; Scharovsky, O. Graciela; Matar, Pablo; Mazzolini, Guillermo (American Association for Cancer Research, 2009-11)
    PURPOSE: Interleukin-12 (IL-12) is an immunostimulatory cytokine with potent antitumor effects in several animal models. However, serious toxicity has been associated with its systemic application in humans. Gene transfer ...
  • Scharovsky, O. Graciela; Mainetti, Leandro Ernesto; Rozados, Viviana R. (Multimed Inc., 2009-03)
    The introduction of the “maximum tolerated dose” in usual treatment protocols (and its concomitant overt toxicity) made necessary the imposition of rest periods between cycles of therapy—a practice that not only involves ...
  • Scharovsky, O. Graciela; Matar, Pablo; Rozados, Viviana R.; Rico, María José; Zacarías Fluck, Mariano; Mainetti, Leandro Ernesto; Fernández Zenobi, María Virginia (Fundación Revista Medicina (Buenos Aires), 2012-02)
    La investigación básica y pre-clínica en oncología celular y molecular son pilares fundamentales en los que se apoyan la mayoría de los adelantos en la terapéutica del cáncer. Los hallazgos obtenidos y su aplicación en la ...
  • Rico, María José; Rozados, Viviana R.; Mainetti, Leandro Ernesto; Zacarías Fluck, Mariano; Matar, Pablo; Scharovsky, O. Graciela (MORION LLC, 2012-03)
    Aim: Experimental and clinical studies showed that the administration of cyclophosphamide (Cy) in low doses leads to an enhancement of the antitumor immune response. Our objective was to study the modulation, if any, by ...
  • Gurzov, Esteban N.; Nabha, Sanaa M.; Yamamoto, Hamilto; Meng, Hong; Scharovsky, O. Graciela; Bonfil, R. Daniel (BioMed Central, 2007-10-01)
    Background Despite significant advancement in breast cancer therapy, there is a great need for a better understanding of the mechanisms involved in breast carcinogenesis and progression, as well as of the role of epigenetic ...
  • Scharovsky, O. Graciela; Matar, Pablo; Zacarías Fluck, Mariano; Rico, María José; Rabinovich, Gabriel A. (Sociedad Española de Inmunología, 2006-04)
    Tumors must circumvent the immune response of the host to become clinically detectable. For this purpose, malignant cells have devised multiple strategies to thwart immune attack. These mechanisms are suggested to ...
  • Rozados, Viviana R.; Hinrichsen, Lucila Isabel; McDonnel, José; Scharovsky, O. Graciela (BioMed Central; "Regina Elena" National Cancer Institute, Italy, 1905-06-27)
    Our previous demonstration of an antimetastatic effect of lovastatin, both in rat sarcoma and lymphoma tumor-models, as well as the fact that lovastatin and radiation are able to stop the cell cycle in different phases, ...
  • Ciocca, Daniel R.; Rozados, Viviana R.; Cuello Carrión, F. Darío; Gervasoni, Silvia I.; Matar, Pablo; Scharovsky, O. Graciela (Springer, 2003-01)
    Heat shock protein 27 (Hsp27) and Hsp70 have been involved in resistance to anticancer drugs in human breast cancer cells growing in vitro and in vivo. In this study, we examined the expression of Hsp25 (the rodent homologue ...
  • Arestegui, Mirta B.; Gualtieri S., Catalina; Domínguez, Javier; Scharovsky, O. Graciela (Facultad de Veterinaria y Zootecnia-UNAM, 2001-04)
    Non-specific resistance is a fundamental component of the host immune response. The mononuclear phagocytic system (MPS) is part of innate resistance effector mechanisms, and is involved in several homeostatic, inflammatory and ...
  • Matar, Pablo; Alaniz, Laura; Rozados, Viviana R.; Aquino, Jorge B.; Malvicini, Mariana; Atorrasagasti, Catalina; Gidekel, Manuel; Silva, Marcelo; Scharovsky, O. Graciela; Mazzolini, Guillermo (BioMed Central, 2009-03-06)
    Increasing evidence suggests that immune responses are involved in the control of cancer and that the immune system can be manipulated in different ways to recognize and attack tumors. Progress in immune-based strategies ...

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