Spectroflurimetric study of estrogen-cyclodextrin inclusion complexes in aqueous systems

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dc.creator Pérez, Rocío Laura
dc.creator Escandar, Graciela Mónica
dc.date.accessioned 2018-11-21T13:33:26Z
dc.date.available 2018-11-21T13:33:26Z
dc.date.issued 2013-02-21
dc.identifier.issn 0003-2654
dc.identifier.uri http://hdl.handle.net/2133/13469
dc.description For the first time, the spectrofluorimetric properties of estrone (E1), 17β-estradiol (E2), estriol (E3), and 17α-ethinylestradiol (EE2) are studied in aqueous solutions after the addition of native and derivative cyclodextrins. In contrast to previous reports, the behavior of the systems is analysed in the absence of organic solvents able to modify the guest-host interaction. The significant differences between the obtained association constants with those reported in solvent mixtures are shown and discussed. In order to evaluate the influence of both the estrogen structure and the presence of cyclodextrin substituents in the inclusion phenomena, fluorescent and acid-base behaviors of the systems are compared and discussed. The interaction of estrogens with micellar media formed by selected surfactants is also studied. It is demonstrated that estrogen-cyclodextrin complexes in aqueous solution are useful for improving fluorimetric detection limits and, since cyclodextrins are non-toxic and mitigate most of the solubility problems which require the use of organic solvents, the studied complexes are excellent candidates for extraction, separation, pre-concentration and removal processes maintaining the principles of the green analytical chemistry. es
dc.description.sponsorship Universidad Nacional de Rosario es
dc.description.sponsorship Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET): Project PIP 1950 es
dc.description.sponsorship Agencia Nacional de Promoción Científica y Tecnológica (ANPCyT): Project PICT 2010-0084 es
dc.format application/pdf
dc.language.iso eng es
dc.publisher Royal Society of Chemistry es
dc.rights openAccess es
dc.rights.uri http://creativecommons.org/licenses/by-nc-sa/2.5/ar/ *
dc.subject Fluorescence es
dc.subject Cyclodextrin es
dc.subject Estrogens es
dc.title Spectroflurimetric study of estrogen-cyclodextrin inclusion complexes in aqueous systems es
dc.rights.holder Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas es
dc.rights.holder Royal Society of Chemistry es
dc.rights.holder Perez, Rocío Laura es
dc.rights.holder Escandar, Graciela Mónica es
dc.relation.publisherversion http://dx.doi.org/10.1039/C2AN36395J es
dc.relation.publisherversion https://pubs.rsc.org/en/Content/ArticleLanding/2013/AN/c2an36395j#!divAbstract es


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