Multivariate calibration-assisted high-performance liquid chromatography with dual UV and fluorimetric detection for the analysis of natural and synthetic sex hormones in environmental waters and sediments

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dc.creator Pérez, Rocío Laura
dc.creator Escandar, Graciela Mónica
dc.date.accessioned 2018-06-14T13:52:24Z
dc.date.available 2018-06-14T13:52:24Z
dc.date.issued 2016-02
dc.identifier.issn 0269-7491
dc.identifier.uri http://hdl.handle.net/2133/11454
dc.description A green method is reported based on non-sophisticated instrumental for the quantification of seven natural and synthetic estrogens, three progestagens and one androgen in the presence of real interferences. The method takes advantage of: (1) chromatography, allowing total or partial resolution of a large number of compounds, (2) dual detection, permitting selection of the most appropriate signal for each analyte and, (3) second-order calibration, enabling mathematical resolution of incompletely resolved chromatographic bands and analyte determination in the presence of interferents. Consumption of organic solvents for cleaning, extraction and separation are markedly decreased because of the coupling with MCR-ALS (multivariate curve resolution/alternating least-squares) which allows the successful resolution in the presence of other co-eluting matrix constituents. Rigorous IUPAC detection limits were obtained: 6–24 ng L−1 in water, and 0.1–0.9 ng g−1 in sediments. Relative prediction errors were 2–10% (water) and 1–8% (sediments). es
dc.description.sponsorship Universidad Nacional de Rosario (Argentina): Project BIO 237 es
dc.description.sponsorship Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET): Project PIP 0163 es
dc.description.sponsorship Agencia Nacional de Promoción Científica y Tecnológica (ANPCyT): PICT 2013-0136 es
dc.format application/pdf
dc.format.extent 114-122 en
dc.language.iso eng es
dc.publisher Elsevier es
dc.rights openAccess es
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es *
dc.subject High-performance-liquid Chromatography es
dc.subject Dual UV-fluorescence Detection es
dc.subject Multivariate Curve Resolution es
dc.subject Endocrine Disruptors es
dc.subject Environmental Samples es
dc.title Multivariate calibration-assisted high-performance liquid chromatography with dual UV and fluorimetric detection for the analysis of natural and synthetic sex hormones in environmental waters and sediments es
dc.rights.holder Universidad Nacional de Rosario es
dc.rights.holder Elsevier es
dc.rights.holder Pérez, Rocío Laura es
dc.rights.holder Escandar, Graciela Mónica es
dc.relation.publisherversion https://www.sciencedirect.com/science/article/pii/S0269749115301846 es
dc.relation.publisherversion http://dx.doi.org/10.1016/j.envpol.2015.11.024 es
dc.rights.text Atribución-NoComercial-SinDerivadas 4.0 Internacional (CC BY-NC-ND 4.0) es
dc.citation.title Environmental Pollution en
dc.citation.volume 209 en
dc.citation.volume 209 en
dc.description.fil Fil: Pérez, Rocío Laura. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Química Rosario (IQUIR-CONICET); Argentina. es
dc.description.fil Fil: Escandar, Graciela Mónica. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Química Rosario (IQUIR-CONICET); Argentina. es


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