Are Changes in the Wnt/β-Catenin Pathway Involved in Cocaine and Stress-Induced Long-Term Neuroadaptations?

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dc.contributor.other Cerchiara, Florencia: for their English technical assistance
dc.creator Cuesta, Santiago
dc.creator Pacchioni, Alejandra Maria
dc.date.accessioned 2018-06-08T22:41:15Z
dc.date.available 2018-06-08T22:41:15Z
dc.date.issued 2017-10-03
dc.identifier.issn 2474-5049 es
dc.identifier.uri http://hdl.handle.net/2133/11427
dc.description Drug addiction has been defined as a chronic relapsing brain disease, characterized by compulsive drug seeking and use, despite harmful consequences. This phenomenon has been extensively studied and the use of animal models has contributed to elucidate neurobiological bases of the different stages in the addiction process. For the past years, we have been studying the role of the Wnt (Wingless-related integration site) pathways in cocaine-induce neuroadaptations by using the behavioral sensitization paradigm to model addiction-like behaviors. The Wnt pathways are critical during the development of both the central and peripheral nervous systems. In particular, we centered our attention on the Wnt/β-catenin or canonical pathway. This pathway mediates the stabilization and nuclear translocation of the final effector β-catenin, where it can promote the expression of different target genes. Our findings reveal a specific spatiotemporal participation of the Wnt/β-catenin pathway in cocaine-induced behavioral sensitization. We found that while the initiation or development of sensitization involves an inhibition in the Prefrontal Cortex’s canonical pathway, the expression is related with activation in the Nucleus Accumbens. Furthermore, we recently discover that stress during adolescence has an impact on cocaine-induced effect in adulthood. Intriguingly, we also found that the exposure to this early life stress influence the activity of the Wnt/β-catenin pathway, proposing that this signaling pathway could be mediating the proactive effect of stress on drug properties. In this manuscript, we cover different mechanisms that may underlie cocaine- and stress-induced changes in the Wnt canonical pathway. We also revise the idea of this pathway as a common target for adolescent stress and for the vulnerability to drug abuse later in life. We suggest that the canonical Wnt pathway constitutes a promising target that may open a door to new therapeutic strategies for the treatment of cocaine addiction. es
dc.format application/pdf
dc.format.extent 112-120 es
dc.language.iso eng es
dc.publisher Elyns Group es
dc.rights openAccess es
dc.rights.uri http://creativecommons.org/publicdomain/zero/1.0/ *
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es *
dc.subject Cocaine es
dc.subject Sensitization es
dc.subject Stress es
dc.subject Vulnerability to Addiction es
dc.title Are Changes in the Wnt/β-Catenin Pathway Involved in Cocaine and Stress-Induced Long-Term Neuroadaptations? es
dc.type article
dc.type artículo
dc.type publishedVersion
dc.rights.holder Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. es
dc.rights.holder Santiago Cuesta es
dc.rights.holder Alejandra M. Pacchioni es
dc.rights.holder Elyns Group LLC es
dc.relation.publisherversion https://www.elynsgroup.com/journal/article/are-changes-in-the-wnt-catenin-pathway-involved-in-cocaine-and-stress-induced-long-term-neuroadaptations es
dc.rights.text Atribución 4.0 Internacional (CC BY 4.0) es
dc.citation.title Journal of Addiction and Preventive Medicine es
dc.citation.volume 2(2) es
dc.description.fil Fil: Cuesta, Santiago. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas; Argentina. es
dc.description.fil Fil: Cuesta, Santiago. Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET); Argentina. es
dc.description.fil Fil: Pacchioni, Alejandra Maria. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas; Argentina. es
dc.description.fil Fil: Pacchioni, Alejandra Maria. Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET); Argentina. es
dc.type.collection articulo
dc.type.version publishedVersion es


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