Metformin and propranolol combination prevents cancer progression and metastasis in different breast cancer models

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dc.creator Rico, María José
dc.creator Baglioni, María
dc.creator Bondarenko, Maryna
dc.creator Laluce, Nahuel Cesatti
dc.creator Rozados, Viviana R.
dc.creator André, Nicolas
dc.creator Carré, Manon
dc.creator Scharovsky, O. Graciela
dc.creator Márquez, Mauricio Menacho
dc.date.accessioned 2018-05-31T18:20:11Z
dc.date.available 2018-05-31T18:20:11Z
dc.date.issued 2016-12-01
dc.identifier.issn 1949-2553 es
dc.identifier.uri http://hdl.handle.net/2133/11407
dc.description Discovery of new drugs for cancer treatment is an expensive and time-consuming process and the percentage of drugs reaching the clinic remains quite low. Drug repositioning refers to the identification and development of new uses for existing drugs and represents an alternative drug development strategy. In this work, we evaluated the antitumor effect of metronomic treatment with a combination of two repositioned drugs, metformin and propranolol, in triple negative breast cancer models. By in vitro studies with five different breast cancer derived cells, we observed that combined treatment decreased proliferation (P < 0.001), mitochondrial activity (P < 0.001), migration (P < 0.001) and invasion (P < 0.001). In vivo studies in immunocompetent mice confirmed the potential of this combination in reducing tumor growth (P < 0.001) and preventing metastasis (P < 0.05). Taken together our results suggest that metformin plus propranolol combined treatment might be beneficial for triple negative breast cancer control, with no symptoms of toxicity. es
dc.description.sponsorship “Agencia Nacional de Promoción Científica y Tecnológica” PICT2014-2025 and “Instituto Nacional del Cáncer” (National Cancer Institute of Argentina; Asistencia Financiera a proyectos de investigación en cáncer de origen nacional III) to MM-M, by ¨Universidad Nacional de Rosario¨ 1MED 321 to OGS, by foundations LN13 La Vie and Les Amis de Charles, as well as by ReSOP (Timone Hospital). MVB’s salary has been supported by the “Instituto Nacional del Cáncer” scholarship program. MB’s fellowship has been funded by ITMO Cancer, from the « Institut National du Cancer » (National Cancer Institute of France). es
dc.format application/pdf
dc.format.extent 2874-2889 es
dc.language.iso eng es
dc.publisher Rapamycin Press es
dc.rights openAccess es
dc.rights.uri https://creativecommons.org/licenses/by/3.0/ *
dc.subject Breast cancer es
dc.subject Metronomics es
dc.subject Drug repositioning es
dc.subject Metformin es
dc.subject Propranolol es
dc.title Metformin and propranolol combination prevents cancer progression and metastasis in different breast cancer models es
dc.type article
dc.type artículo
dc.type publishedVersion
dc.rights.holder Autores es
dc.audience
dc.audience
dc.relation.publisherversion https://doi.org/10.18632/oncotarget.13760 es
dc.rights.text Oncotarget applies the Creative Commons Attribution 3.0 License (CC BY 3.0) to all works we publish (read the human-readable summary or the full license legal code). Under the CC BY, authors retain ownership of the copyright for their article, but authors allow anyone to download, reuse, reprint, modify, distribute, and/or copy articles in Oncotarget, so long as the original authors and source are cited. es
dc.citation.title Metformin and propranolol combination prevents cancer progression and metastasis in different breast cancer models es
dc.description.fil Fil: Rico, María José. Institute of Experimental Genetics. School of Medical Sciences. National University of Rosario; Rosario; Argentina es
dc.description.fil Fil: Bondarenko, Maryna. Aix-Marseille Université. Inserm UMR_S 911. Centre de Recherche en Oncologie biologique et Oncopharmacologie. Faculté de Pharmacie; Marseille; France es
dc.description.fil Fil: Laluce, Nahuel Cesatti. Instituto de Genética Experimental. Facultad de Ciencias Médicas. Universidad Nacional de Rosario; Rosario; Argentina es
dc.description.fil Fil: Rozados, Viviana R. Institute of Experimental Genetics. School of Medical Sciences. National University of Rosario; Rosario; Argentina es
dc.description.fil Fil: André, Nicolas. Service d'Hématologie and Oncologie Pédiatrique. AP-HM. Boulevard Jan Moullin; Marseille; France es
dc.description.fil Fil: Carré, Manon. Aix-Marseille Université. Inserm UMR_S 911. Centre de Recherche en Oncologie biologique et Oncopharmacologie. Faculté de Pharmacie; Marseille; France es
dc.description.fil Fil: Scharovsky, Graciela Olga. Universidad Nacional de Rosario. Consejo de Investigaciones UNR, Facultad de Ciencias Médicas; Argentina es
dc.description.fil Fil: Márquez, Mauricio Menacho. Instituto de Genética Experimental. Facultad de Ciencias Médicas. Universidad Nacional de Rosario; Rosario; Argentina es
dc.description.fil Fil: Baglioni, María. Instituto de Genética Experimental. Facultad de Ciencias Médicas. Universidad Nacional de Rosario; Rosario; Argentina es
dc.type.collection articulo
dc.type.version publishedVersion es


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