In vivo measurement of the rate constant of liver handling of glucose and glucose uptake by insulin-dependent tissues, using a mathematical model for glucose homeostasis in diabetic rats

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dc.creator Lombarte, Mercedes
dc.creator Lupo, Maela
dc.creator Fina, Brenda
dc.creator Campetelli, Germán
dc.creator Basualdo, Marta
dc.creator Buzalaf, Marilia
dc.creator Rigalli, Alfredo
dc.date.accessioned 2017-12-09T17:54:39Z
dc.date.available 2017-12-09T17:54:39Z
dc.date.issued 2017-12-08
dc.identifier.uri http://hdl.handle.net/2133/10176
dc.description Diabetes mellitus is a disease that affects glucose homeostasis. The World Health Organization informs that there are over 347 million people in the world with diabetes. The diagnosis and characterization of glucose homeostasis in different metabolic conditions are subjects of great importance with high clinical impact. There are many mathematical models that describe the gluco‑regulatory system in detail. However, the use of these models is limited because they have a large number of mathematical equations and parameters and they require complex methodologies to estimate of them. This forced to work with average values that decrease the validity of results and the applicability of the models. In this study two mathematical models for rats with diabetes mellitus were developed. The difference between these models and others lies in the possibility of obtaining all parameters for each animal from simple measurements (glucose and insulin plasma levels). Moreover, the models allow to measure in vivo the different physiological processes involved in glucose homeostasis in animals: insulin secretion and its plasma clearance, absorption of insulin from a subcutaneous injection, the liver handling of glucose, intestine absorption of glucose, glucose uptake rate of insulin-independent tissues, glucose uptake rate of insulin-dependent tissues, and renal glucose excretion. es
dc.format text/plain
dc.format application/pdf
dc.format text/plain
dc.language.iso eng es
dc.rights openAccess es
dc.rights.uri http://creativecommons.org/publicdomain/zero/1.0/ *
dc.subject in silico es
dc.subject mathematical model es
dc.subject diabetes es
dc.title In vivo measurement of the rate constant of liver handling of glucose and glucose uptake by insulin-dependent tissues, using a mathematical model for glucose homeostasis in diabetic rats es
dc.type other
dc.type Material Didáctico
dc.type.collection material_didactico
dc.type.other Simulación es
lom.educational.context Posgrado es
lom.educational.difficulty Altamente Dificultoso es
lom.educational.interactivity activa es
lom.educational.typicalAgeRange adultos es
lom.learningResourceType Simulación


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